{"id":25622,"date":"2018-03-09T09:17:05","date_gmt":"2018-03-09T09:17:05","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-inmunologico-en-la-esclerosis-multiple-familiar-citocinas-moleculas-de-adhesion-y-receptores-de-quimiocinas\/"},"modified":"2018-03-09T09:17:05","modified_gmt":"2018-03-09T09:17:05","slug":"estudio-inmunologico-en-la-esclerosis-multiple-familiar-citocinas-moleculas-de-adhesion-y-receptores-de-quimiocinas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-inmunologico-en-la-esclerosis-multiple-familiar-citocinas-moleculas-de-adhesion-y-receptores-de-quimiocinas\/","title":{"rendered":"Estudio inmunol\u00f3gico en la esclerosis m\u00faltiple familiar: citocinas, mol\u00e9culas de adhesi\u00f3n y receptores de quimiocinas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana Malagelada Seckler <\/strong><\/h2>\n<p>En la esclerosis m\u00faltiple (em) existe una agregaci\u00f3n familiar que viene demostrada por la mayor incidencia de la enfermedad en los familiares de los pacientes, la elevada concordancia en los gemelos monocigotos y la existencia de una susceptibilidad gen\u00e9tica ligada a determinados haplotipos del sistema hla. Por otro lado, existen evidencias del car\u00e1cter autoinmune de la em y el aumento de la incidencia de otras enfermedades autoinmunes en los familiares de los pacientes.  hemos querido comprobar la hip\u00f3tesis de que los pacientes con em y sus familiares sanos comparten alteraciones inmunol\u00f3gicas que podr\u00edan reflejar la mayor susceptibilidad a padecer la enfermedad.  para ello hemos estudiado, mediante tinci\u00f3n de superficie e intracitoplasm\u00e1tica en c\u00e9lulas mononucleares de sangre perif\u00e9rica de 13 familias em multiplex (21 pacientes con emrr, 5 pacientes con emsp y 29 familiares sanos de primer o segundo grado) y 26 controles sanos apareados por edad y sexo, seis mol\u00e9culas que juegan un demostrado papel en la patogenia de la em: dos citocinas (ifn-gama, il-6), dos mol\u00e9culas de adhesi\u00f3n (l-selectina, vla-4) y dos receptores de quimiocinas (ccr5 y cxcr3).  los resultados del estudio han demostrado un aumento de la producci\u00f3n de ifn-gama por los linfocitos de los pacientes y sus familiares sanos con respecto a los controles sanos, as\u00ed como una menor expresi\u00f3n de la l-selectina en los monocitos de los controles con respecto a los pacientes y sus familiares sanos.  demuestran estos hallazgos que los pacientes con em y sus familiares sanos presentan linfocitos con mayor potencial proinflamatorio y monocitos con mayor grado de activaci\u00f3n que la poblaci\u00f3n general. Estos datos apoyan la existencia de cambios inmunol\u00f3gicos, no s\u00f3lo en los pacientes con em, sino tambi\u00e9n en los sujetos con m\u00e1s elevado riesgo de padecer la enfermedad.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio inmunol\u00f3gico en la esclerosis m\u00faltiple familiar: citocinas, mol\u00e9culas de adhesi\u00f3n y receptores de quimiocinas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio inmunol\u00f3gico en la esclerosis m\u00faltiple familiar: citocinas, mol\u00e9culas de adhesi\u00f3n y receptores de quimiocinas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana Malagelada Seckler <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/09\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Xavier Montalb\u00e1n Gair\u00edn<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  jose Zarranz imirizaldu <\/li>\n<li> Fonollosa i pla vicent (vocal)<\/li>\n<li> Bosch gil jospe \u00e1ngel (vocal)<\/li>\n<li>domingo Arbizu urdiain (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana Malagelada Seckler En la esclerosis m\u00faltiple (em) existe una agregaci\u00f3n familiar que viene demostrada por la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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