{"id":25629,"date":"2018-03-09T09:17:05","date_gmt":"2018-03-09T09:17:05","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/factores-geneticos-implicados-en-la-modulacion-de-la-anticoagulacion-oral-con-acenocumarol\/"},"modified":"2018-03-09T09:17:05","modified_gmt":"2018-03-09T09:17:05","slug":"factores-geneticos-implicados-en-la-modulacion-de-la-anticoagulacion-oral-con-acenocumarol","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/navarra\/factores-geneticos-implicados-en-la-modulacion-de-la-anticoagulacion-oral-con-acenocumarol\/","title":{"rendered":"Factores gen\u00e9ticos implicados en la modulaci\u00f3n de la anticoagulaci\u00f3n oral con acenocumarol"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Zarza Ortiz Jos\u00e9 Javier <\/strong><\/h2>\n<p>Introducci\u00f3n  el acenocumarol es el principal anticoagulante oral utilizado en espa\u00f1a y latinoam\u00e9rica mientras que en otros pa\u00edses se utiliza la warfarina. Existe una amplia variabilidad interindividual en la sensibilidad a estos f\u00e1rmacos. se ha sugerido la importancia de factores gen\u00e9ticos en la sensibilidad a la warfarina pero no se conoce si los mismos tienen o no importancia en la sensibilidad al acenocumarol.  objetivos  estudiar la influencia de las variantes gen\u00e9ticas de cyp2c9 (cyp2c9*2, cyp2c9*3,lle181leu, leu208val y c-1189) y de otras variables (edad, sexo, consumo de f\u00e1rmacos) en la sensibilidad al acenocumarol en una poblaci\u00f3n de sujetos anticoagulados. Identificar nuevas variantes gen\u00e9ticas de cyp2c9 y del prop\u00e9ptido del factor vii de la coagulaci\u00f3n e investigar su influencia en la sensibilidad al acenocumarol.  material y m\u00e9todos  se estudiaron 113 pacientes consecutivos en tratamiento con dosis estables de acenocumarol y con un grado similar de anticoagulaci\u00f3n, y se agruparon seg\u00fan las dosis requerida; baja (n=43), intermedia (n=45) y alta (n=21). se excluyeron cuatro pacientes por no reunir los criterios de inclusi\u00f3n. se realizaron reacciones de pcr y digesti\u00f3n con enzimas de restricci\u00f3n para detectar las variantes gen\u00e9ticas. Se secuenciaron los nueve ex\u00f3nes de cyp2c9 y de las regiones intr\u00f3nicas adyacentes y del prop\u00e9ptido del factor vii en un grupo seleccionado de pacientes para detectar nuevas variantes con posible importancia en la sensibilidad al tratamiento.  resultados  cyp2c9*3, cyp2c9*2 y la edad son factores independientes de riesgo de requerir una dosis baja de acenocumarol. La influencia de cyp2c9*3 en la sensibilidad al acenocumarol es muy mayor que la del cyp2c9*2. No se encontr\u00f3 ningun portador de las variantes lle181leu ni leu208val. La variante c-1189 del promotor de cyp2c9 no se asocia con los requerimientos de acenocumarol ya que est\u00e1 en desequilibrio de ligamiento con c<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Factores gen\u00e9ticos implicados en la modulaci\u00f3n de la anticoagulaci\u00f3n oral con acenocumarol<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Factores gen\u00e9ticos implicados en la modulaci\u00f3n de la anticoagulaci\u00f3n oral con acenocumarol <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Zarza Ortiz Jos\u00e9 Javier <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/09\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Mar\u00eda Hermida Santos<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ana Villegas mart\u00ednez <\/li>\n<li>eduardo Alegria ezquerra (vocal)<\/li>\n<li>evaristo Feli\u00fa frasnedo (vocal)<\/li>\n<li>ignacio Alberca silva (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Zarza Ortiz Jos\u00e9 Javier Introducci\u00f3n el acenocumarol es el principal anticoagulante oral utilizado en espa\u00f1a y latinoam\u00e9rica [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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