{"id":25703,"date":"2018-03-09T09:17:11","date_gmt":"2018-03-09T09:17:11","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/hepatitis-b-oculta-en-pacientes-coinfectados-por-vhc-y-vih-resistencias-a-lamivudina-en-nuestro-medio\/"},"modified":"2018-03-09T09:17:11","modified_gmt":"2018-03-09T09:17:11","slug":"hepatitis-b-oculta-en-pacientes-coinfectados-por-vhc-y-vih-resistencias-a-lamivudina-en-nuestro-medio","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/hepatitis-b-oculta-en-pacientes-coinfectados-por-vhc-y-vih-resistencias-a-lamivudina-en-nuestro-medio\/","title":{"rendered":"Hepatitis b oculta en pacientes coinfectados por vhc y vih. resistencias a lamivudina en nuestro medio"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Daza Garc\u00eda Rosa M. <\/strong><\/h2>\n<p>La realizaci\u00f3n de esta tesis ha supuesto un gran esfuerzo por nuestra parte, finalmente hemos cumplido los objetivos que nos planteamos:  * detectamos una preValencia de hbo (hepatitis b oculta) en la poblaci\u00f3n coinfectada con vih y vhc de granada de un 4,9%., No encontramos diferencias significativas para ning\u00fan par\u00e1metro epidemiol\u00f3gico, virol\u00f3gico ni bioqu\u00edmico-cl\u00ednico.  * el genotipo de vhb m\u00e1s prevalente en nuestra \u00e1rea geogr\u00e1fica es el d, seguido del a., Hemos detectado dos genotipos mixtos a\/g., Sin embargo, el genotipo a  ha sido el m\u00e1s prevalente, alcanzando significaci\u00f3n estad\u00edstica, en los pacientes vih y en los pacientes advp.  * existe una buena correlaci\u00f3n entre la hibridaci\u00f3n reversa y la secuenciaci\u00f3n para la determianci\u00f3n del genotipo de vhb y mutaciones de resistencia a la lamivundina, aunque la t\u00e9cnica de hibridaci\u00f3n reversa ha mostrado una mayor sensibilidad que la secuenciaci\u00f3n y una mayor resoluci\u00f3n a la hora de detectar especies minoritarias.  * en nuestro medio, la mayor\u00eda de los fracasos a lamivudina se explican por la aparici\u00f3n de mutaciones de resitencia en el gen pol del vhb., La frecuencia y el tipo de mutaciones no son genotipo dependientes (para los genotipos a y d).  * la tasa de resistencia primarias a la lamivudina en los pacientes con hepatitis cr\u00f3nica por vhb y coinfectados por vih de la cohorte que hemos estudiado, no justifica por el momento que esta prueba deba realizarse antes de iniciar el tratamiento con este f\u00e1rmaco aunque el paciente lo haya recibido como parte del r\u00e9gimen antirretrovial.  creemos que nuestro trabajo aporta nuevos conocimientos en el campo de la hepatitis b cr\u00f3nica su evoluci\u00f3n tratamiento y pron\u00f3stico.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Hepatitis b oculta en pacientes coinfectados por vhc y vih. resistencias a lamivudina en nuestro medio<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Hepatitis b oculta en pacientes coinfectados por vhc y vih. resistencias a lamivudina en nuestro medio <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Daza Garc\u00eda Rosa M. <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/09\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Federico Garc\u00eda Garc\u00eda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: gonzalo Pi\u00e9drola angulo <\/li>\n<li>Antonio Rodriguez torres (vocal)<\/li>\n<li>ascensi\u00f3n Bernal zamora (vocal)<\/li>\n<li>Antonio Ordu\u00f1a domingo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Daza Garc\u00eda Rosa M. La realizaci\u00f3n de esta tesis ha supuesto un gran esfuerzo por nuestra parte, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[27830,10196,6958,74727,22083,694],"class_list":["post-25703","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-antonio-orduna-domingo","tag-antonio-rodriguez-torres","tag-ascension-bernal-zamora","tag-daza-garcia-rosa-m","tag-federico-garcia-garcia","tag-gonzalo-piedrola-angulo"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/25703","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=25703"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/25703\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=25703"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=25703"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=25703"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}