{"id":25704,"date":"2018-03-09T09:17:11","date_gmt":"2018-03-09T09:17:11","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/genotipado-mediante-secuenciacion-subtipado-y-deteccion-de-formas-circulantes-recombinantes-del-vih-1\/"},"modified":"2018-03-09T09:17:11","modified_gmt":"2018-03-09T09:17:11","slug":"genotipado-mediante-secuenciacion-subtipado-y-deteccion-de-formas-circulantes-recombinantes-del-vih-1","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/genotipado-mediante-secuenciacion-subtipado-y-deteccion-de-formas-circulantes-recombinantes-del-vih-1\/","title":{"rendered":"Genotipado mediante secuenciaci\u00f3n, subtipado y detecci\u00f3n de formas circulantes recombinantes del vih-1"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Sonia Su\u00e1rez L\u00f3pez <\/strong><\/h2>\n<p>Evaluamos la aparici\u00f3n en andaluc\u00eda oriental de nuevos subtipos formas circulantes recombinantes del vih-1, as\u00ed como estudiar las mutaciones de resistencia que desarrolla el virus para proteasa y transcriptasa inversa, correlacionar las mismas con el tipo de fracaso terap\u00e9utico que presenta el paciente y ver si existen diferencias entre subtipos b y no-b en la selecci\u00f3n de esas mutaciones.  asimismo, evaluamos la utilidad de la realizaci\u00f3n de un test de resistencia genot\u00edpico (secuenciaci\u00f3n), para realizar cambio de tratamiento antirretroviral en pacientes con fracaso terap\u00e9utico y compararlo con otro grupo en el que el cambio de tratamiento se realiza seg\u00fan criterios de historia de tratamiento antirretroviral. Se obtienen mejores resultados de respuesta virol\u00f3gica en el grupo en que se realiza el test de resistencias.  hemos comparado distintos algoritmos de interpretaci\u00f3n de las mutaciones de resistencia para ver qu\u00e9 grado de concordancia presentan entre ellos a la hora de informar las resistencias a los antirretroviales, observando, que esta concordancia es menor para la familia de los inhibidores de la trasncriptasa inversa an\u00e1logos de nucle\u00f3sidos (ddc, ddi, d4t y abc).  comparamos adem\u00e1s, la concordancia entre la informaci\u00f3n genot\u00edpica de las resistencias junto con el informe del fenotipo virtual y obtenemos como resultado que disminuye la concordancia para an\u00e1logos de nucle\u00f3sidos y las discordancias aparecen sobre todo cuando el genotipo informa m\u00e1s resitencia que el fenotipo virtual.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Genotipado mediante secuenciaci\u00f3n, subtipado y detecci\u00f3n de formas circulantes recombinantes del vih-1<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Genotipado mediante secuenciaci\u00f3n, subtipado y detecci\u00f3n de formas circulantes recombinantes del vih-1 <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Sonia Su\u00e1rez L\u00f3pez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/09\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Federico Garc\u00eda Garc\u00eda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: gonzalo Pi\u00e9drola angulo <\/li>\n<li>Antonio Rodriguez torres (vocal)<\/li>\n<li>Antonio Ordu\u00f1a domingo (vocal)<\/li>\n<li>ascensi\u00f3n Bernal zamora (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sonia Su\u00e1rez L\u00f3pez Evaluamos la aparici\u00f3n en andaluc\u00eda oriental de nuevos subtipos formas circulantes recombinantes del vih-1, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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