{"id":25731,"date":"2018-03-09T09:17:14","date_gmt":"2018-03-09T09:17:14","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sa%c2%adntesis-de-heterociclos-funcionalizados-va%c2%ada-reacciones-de-ciclacion-anionica-intramolecular\/"},"modified":"2018-03-09T09:17:14","modified_gmt":"2018-03-09T09:17:14","slug":"sa%c2%adntesis-de-heterociclos-funcionalizados-va%c2%ada-reacciones-de-ciclacion-anionica-intramolecular","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/burgos\/sa%c2%adntesis-de-heterociclos-funcionalizados-va%c2%ada-reacciones-de-ciclacion-anionica-intramolecular\/","title":{"rendered":"S\u00edntesis de heterociclos funcionalizados v\u00edareacciones de ciclaci\u00f3n ani\u00f3nica intramolecular"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Yolanda Fern\u00e1ndez Sainz <\/strong><\/h2>\n<p>El desarrollo de nuevas estrategias sint\u00e9ticas dirigidas hacia la preparaci\u00f3n de heterociclos funcionalizados es un tema de gran inter\u00e9s en s\u00edntesis org\u00e1nica. Con este objetivo, se ha estudiado la reactividad de diferentes compuestos organol\u00edticos funcionalizados frente a dobles y triples enlaces en posibles reacciones de carbolitaci\u00f3n intramolecular. De este modo se ha descrito la carbolitiaci\u00f3n intramolecular v\u00eda un cierre regioselectivo 5-exo de n-(2-litioalil)aminas y sistemas relacionados que presentan en su estructura un doble enlace 1,2-disustituido o bien un triple enlace no terminal, dando lugar, tras funcionalizaci\u00f3n, a pirrolidinas e hexahidroindoles doblemente funcionalizados as\u00ed como a indoles funcionalizados en la posici\u00f3n 3.  por otro lado, se ha descrito la posibilidad de llevar a cabo reacciones de ciclaci\u00f3n ani\u00f3nica intramolecular 5-exo-dig \u00f3 6-exo-dig de compuestos organol\u00edticos beta \u00f3 gamma-funcionalizados que presenten un bencino en su estructura. La reacci\u00f3n de los organol\u00edticos intermedios con diferentes electr\u00f3filos permite la preparaci\u00f3n de una amplia variedad de heterociclos benzofusionados de cinco y seis eslabones funcionalizados regioselectivamente.  as\u00ed, se han obtenido indoles, tetrahidrocarbazoles y carbazoles a partir de compuestos organol\u00edticos beta-n-funcionalizados. Tambi\u00e9n es posible llevar a cabo estas reacciones en compuestos organol\u00edticos beta-o y s-funcionalizados, siempre y cuando son sea posible la beta-eliminaci\u00f3n, lo que ha conducido al a obtenci\u00f3n de dibensofuranos y dibenzotiofenos. Esta estrategia tambi\u00e9n ha sido empleada en la preparaci\u00f3n de dihidrofenantridinas, dibenzopiranos, dibenzotiopiranos y 2h-cromenos a partir de organol\u00edticos gamma-n, -o y s- funcionalizados. Esta metodolog\u00eda ha sido extendida a la s\u00edntesis de los correpondientes heterociclos nh, as\u00ed como a la preparaci\u00f3n, por posterior oxidaci\u00f3n, de derivados de fenantridinona, fenantridina, ben<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>S\u00edntesis de heterociclos funcionalizados v\u00edareacciones de ciclaci\u00f3n ani\u00f3nica intramolecular<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 S\u00edntesis de heterociclos funcionalizados v\u00edareacciones de ciclaci\u00f3n ani\u00f3nica intramolecular <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Yolanda Fern\u00e1ndez Sainz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Burgos<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/09\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Roberto Sanz D\u00edez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 joaquin Barluenga mur <\/li>\n<li>claudio Palomo nicolau (vocal)<\/li>\n<li>Juan Bosch cartes (vocal)<\/li>\n<li> Rodr\u00edguez barranco Miguel angel (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Yolanda Fern\u00e1ndez Sainz El desarrollo de nuevas estrategias sint\u00e9ticas dirigidas hacia la preparaci\u00f3n de heterociclos funcionalizados es [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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