{"id":25860,"date":"2018-03-09T09:17:24","date_gmt":"2018-03-09T09:17:24","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-los-transportadores-de-acido-glutamico-en-la-esclerosis-multiple\/"},"modified":"2018-03-09T09:17:24","modified_gmt":"2018-03-09T09:17:24","slug":"estudio-de-los-transportadores-de-acido-glutamico-en-la-esclerosis-multiple","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/pais-vasco-euskal-herriko-unibertsitatea\/estudio-de-los-transportadores-de-acido-glutamico-en-la-esclerosis-multiple\/","title":{"rendered":"Estudio de los transportadores de \u00e1cido glut\u00e1mico en la esclerosis m\u00faltiple"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ainara Vallejo Illarramendi <\/strong><\/h2>\n<p>El \u00e1cido glut\u00e1mico es el neurotransmisor excitatorio m\u00e1s abundante en el sistema nervioso central de los mam\u00edferos, y media la mayor\u00eda de las funciones cerebrales, como el aprendizaje y la memoria. Sin embargo, en concentraciones elevadas es un potente t\u00f3xico capaz de provocar la muerte a neuronas y oligodendrocitos, c\u00e9lulas encargadas de mielinizar los axones en el snc.  los transportadores del \u00e1cido glut\u00e1mico son los encargados de recaptar el glutamato liberado por los terminales nerviosos, y en general, de mantener bajos los niveles de glutamato extracelular. Esto es de vital importancia en la transmisi\u00f3n sin\u00e1ptica, as\u00ed como tambi\u00e9n previene la sobreestimulaci\u00f3n de los receptores de glutamato que desencadenar\u00eda mecanismos excitot\u00f3xicos y muerte celular. Diversos estudios han dado indicios de que la exitotoxicidad contribuye a la muerte oligodendroglial en la enfermedad de la esclerosis m\u00faltiple. Dado que los transportadores de glutamato son las mol\u00e9culas encargadas del mantenimiento de la homeostasis del glutamato, en el presente trabajo se ha estudiado mediante t\u00e9cnicas de biolog\u00eda molecular los transportadores de glutamato eaat1, 2 y 3 en muestras de sangre y autopsias de nervio \u00f3ptico humano. Asimismo, se ha efectuado un estudio comparativo entre las muestras de pacientes con esclerosis m\u00faltiple y de individuos sanos, con objeto de determinar posibles alteraciones en los transportadores a nivel de adn, arn mensajero y prote\u00edna. Los resultados obtenidos en el presente trabajo indican que la expresi\u00f3n y el procesamiento post-transcripcional de los transportadores de \u00e1cido glut\u00e1mico eaat1 y 2 est\u00e1n afectados en los enfermos de esclerosis m\u00faltiple.  dichas alteraciones pueden constituir una respuesta adaptativa al incremento de los niveles de \u00e1cido glut\u00e1mico que se observa en el sistema nervioso central de pacientes con esclerosis m\u00faltiple. En consecuencia, los reguladores positivos de la expresi\u00f3n de los<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de los transportadores de \u00e1cido glut\u00e1mico en la esclerosis m\u00faltiple<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de los transportadores de \u00e1cido glut\u00e1mico en la esclerosis m\u00faltiple <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ainara Vallejo Illarramendi <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 26\/09\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carlos Matute Almau<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis Martinez millan <\/li>\n<li>Luisa Ugedo urruela (vocal)<\/li>\n<li>carmen Montiel l\u00f3pez (vocal)<\/li>\n<li>pere Berbel navarro (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ainara Vallejo Illarramendi El \u00e1cido glut\u00e1mico es el neurotransmisor excitatorio m\u00e1s abundante en el sistema nervioso central [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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