{"id":25883,"date":"2018-03-09T09:17:27","date_gmt":"2018-03-09T09:17:27","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mutaciones-del-gen-har-y-factores-pronosticos-en-cancer-de-prostata\/"},"modified":"2018-03-09T09:17:27","modified_gmt":"2018-03-09T09:17:27","slug":"mutaciones-del-gen-har-y-factores-pronosticos-en-cancer-de-prostata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/navarra\/mutaciones-del-gen-har-y-factores-pronosticos-en-cancer-de-prostata\/","title":{"rendered":"Mutaciones del gen har y factores pron\u00f3sticos en c\u00e1ncer de pr\u00f3stata"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Daniel S\u00e1nchez Zalabardo <\/strong><\/h2>\n<p>Introducci\u00f3n  las hormonas esteroideas tienen mecanismos de acci\u00f3n mediados por sus receptores espec\u00edficos, llamados receptor de andr\u00f3genos, estr\u00f3genos, progesterona, glucocorticoides y mineralcorticoides. Estos receptores son miembros de una superfamilia de receptores. El ar es una prote\u00edna de 919 amino-\u00e1cidos de longitud y con un peso molecular de 98 kilodaltons. Como el resto de los receptores esteroides, el ar tiene cuatro dominios funcionales. El har se encuentra en el brazo largo del cromosoma x (qx 11-12). El har se divide en ocho exones con una longitud  de 2730 pares de bases. La secuencia que codifica el dominio n-terminal se encuentra en el ex\u00f3n 1. El domino de uni\u00f3n al adn se codifica  en los exones 2 y 3. La regi\u00f3n bisagra se codifica en el ex\u00f3n cuatro. El dominio c-terminal se distribuye en los exones 4 al 8. El primer ex\u00f3n contiene dos repeticiones de trinucle\u00f3tidos que codifican una secuencia pliglutamina y otra poliglicina. La secuencia de poliglutamida est\u00e1 codificada por el triplete cag y la de poliglicina por el tracto ggn.  objetivos  1,- estudio de las mutaciones del gen del receptor andr\u00f3genico mediante secuenciaci\u00f3n gen\u00f3mica en adenocarcinoma de pr\u00f3stata cl\u00ednicamente localizado: detecci\u00f3n de la frecuencia de mutaciones del gen har y localizaci\u00f3n y caracterizaci\u00f3n del tipo de mutaciones del gen har en el carcinoma de pr\u00f3stata humano cl\u00ednicamente localizado.  2,- estudio de la relaci\u00f3n de los factores cl\u00ednicos, psa, diferenciaci\u00f3n celular y factores patol\u00f3gicos con las mutaciones del gen del receptor de andr\u00f3geno.  3,- estudio del valor pron\u00f3stico de las mutaciones del gen del receptor androg\u00e9nico en relaci\u00f3n con la supervivencia glboal y con la supervivencia libre de enfermedad.  material y m\u00e9todos  se realiza la secuenciaci\u00f3n gen\u00f3mica del gen har en 67 pacientes diagnosticados de adenocarcinoma de pr\u00f3stata cl\u00ednicamente localizado de los 165 tratados mediante protatecto<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mutaciones del gen har y factores pron\u00f3sticos en c\u00e1ncer de pr\u00f3stata<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mutaciones del gen har y factores pron\u00f3sticos en c\u00e1ncer de pr\u00f3stata <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Daniel S\u00e1nchez Zalabardo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 26\/09\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>David Rosell Costa<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis angel Rioja sanz <\/li>\n<li>Juan  Javier Zudaire bergera (vocal)<\/li>\n<li>joaqu\u00edn Carballido rodr\u00edguez (vocal)<\/li>\n<li> Romero fern\u00e1ndez Francisco j. (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Daniel S\u00e1nchez Zalabardo Introducci\u00f3n las hormonas esteroideas tienen mecanismos de acci\u00f3n mediados por sus receptores espec\u00edficos, llamados [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[17749],"tags":[75171,61396,14430,69603,17762,17761],"class_list":["post-25883","post","type-post","status-publish","format-standard","hentry","category-navarra","tag-daniel-sanchez-zalabardo","tag-david-rosell-costa","tag-joaquin-carballido-rodriguez","tag-juan-javier-zudaire-bergera","tag-luis-angel-rioja-sanz","tag-romero-fernandez-francisco-j"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/25883","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=25883"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/25883\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=25883"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=25883"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=25883"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}