{"id":25930,"date":"2018-03-09T09:17:31","date_gmt":"2018-03-09T09:17:31","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-funcion-endotelial-en-un-modelo-canino-de-shock-hemorragico-grave-tratado-con-salino-hipertonico-vs-sangre\/"},"modified":"2018-03-09T09:17:31","modified_gmt":"2018-03-09T09:17:31","slug":"estudio-de-la-funcion-endotelial-en-un-modelo-canino-de-shock-hemorragico-grave-tratado-con-salino-hipertonico-vs-sangre","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-la-funcion-endotelial-en-un-modelo-canino-de-shock-hemorragico-grave-tratado-con-salino-hipertonico-vs-sangre\/","title":{"rendered":"Estudio de la funci\u00f3n endotelial en un modelo canino de shock hemorr\u00e1gico grave tratado con salino hipert\u00f3nico vs. sangre"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Guzm\u00e1n P\u00e9rez Jos\u00e9 Antonio <\/strong><\/h2>\n<p>Introducci\u00f3n  la hipoxia, es la gran responsable de las alteraciones celulares que conlleva la disfunci\u00f3n multi\u00f3rganica. La isquemia da lugar a la liberaci\u00f3n de mediadores como las citokinas que a su vez hacen que se expresen las mol\u00e9culas  de adhesi\u00f3n (ma) sobre la superficie de las c\u00e9lulas endoteliales y en los polimorfo nucleares (pmn). Dos componentes de estas ma son las integrinas y las icam-1. Por otro lado desde hace m\u00e1s de 20 a\u00f1os se viene incidiendo sobre los beneficios del suero salino hipert\u00f3nico (ssh) en el tratamiento del shock hemorr\u00e1gico.  objetivos  1,- estudiar el comportamiento de las ma en el endotelio vascular y los pmn durante un shock hemorr\u00e1gico grave.  2,- describir el comportamiento de estas ma durante el tratamiento con sangre o con ssh.  3,- analizar la repercusi\u00f3n hemodin\u00e1mica de ambos regimenes de tratamiento.  material y m\u00e9todos  se utilizaron 18 perros se sometieron a un profundo shock. Recuperando a un grupo con sangre + salino normal y a otro grupo de ssh y dextranos. se realizaron estudios hemodin\u00e1micos, bioqu\u00edmicos y de ma en el tiempo basal (to), en el de m\u00e1ximo sangrado (t3) y en el de recuperaci\u00f3n (t4).  resultados  ta disminuy\u00f3 significativamente igual que indice cardiaco, las presiones vesosas centrales y la presi\u00f3n del capilar pulmonar. Como \u00edndice de sufrimiento celular dimsinuy\u00f3 la saturaci\u00f3n venosa de ox\u00edgeno (o2), el exceso de bases y aument\u00f3 el lactato plasm\u00e1tico. Descendi\u00f3 el aporte de o2 celular aumento la extracci\u00f3n y se mantuvo constante el consumo de o2. Tras la reanimaci\u00f3n los par\u00e1metros tendieron a la normalidad, alcanzando la de la mayor\u00eda de ellos pero los del grupo ssh fue mucho m\u00e1s suave que los del grupo sangre.  las integrinas aumentaron su expresi\u00f3n durante t3 y se elevaron a\u00fan m\u00e1s durante la reperfusi\u00f3n. Las icam tuvieron el mismo comportamiento pero la sangre inhibi\u00f3 su expresi\u00f3n.  conclusiones  nuestro modelo de shock es v<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la funci\u00f3n endotelial en un modelo canino de shock hemorr\u00e1gico grave tratado con salino hipert\u00f3nico vs. sangre<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la funci\u00f3n endotelial en un modelo canino de shock hemorr\u00e1gico grave tratado con salino hipert\u00f3nico vs. sangre <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Guzm\u00e1n P\u00e9rez Jos\u00e9 Antonio <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 29\/09\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Eugenio Arevalo Jimenez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Concha ru\u00edz <\/li>\n<li>Miguel Romero moreno (vocal)<\/li>\n<li>Jos\u00e9 ignacio Redondo Garc\u00eda (vocal)<\/li>\n<li>Jes\u00fas Loscertales abril (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Guzm\u00e1n P\u00e9rez Jos\u00e9 Antonio Introducci\u00f3n la hipoxia, es la gran responsable de las alteraciones celulares que conlleva [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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