{"id":25975,"date":"2018-03-09T09:17:34","date_gmt":"2018-03-09T09:17:34","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/polimorfismos-genicos-del-metabolismo-de-los-folatos-e-influencia-del-tratamiento-con-acido-folico\/"},"modified":"2018-03-09T09:17:34","modified_gmt":"2018-03-09T09:17:34","slug":"polimorfismos-genicos-del-metabolismo-de-los-folatos-e-influencia-del-tratamiento-con-acido-folico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/malaga\/polimorfismos-genicos-del-metabolismo-de-los-folatos-e-influencia-del-tratamiento-con-acido-folico\/","title":{"rendered":"Polimorfismos genicos del metabolismo de los folatos e influencia del tratamiento con \u00e1cido folico"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Hidalgo Vazquez Jos\u00e9 Miguel <\/strong><\/h2>\n<p>Los niveles basales de hcy plasm\u00e1tica se encontraron elevados significativamente en el genotipo tt del polimorfismo c677t de la mthfr y en el genotipo gg del polimorfismo a66g de la mtrr, no encontr\u00e1ndose diferencias significativas en los dem\u00e1s genotipos.  se produce un efecto sin\u00e9rgico sobre los niveles de hcy plasm\u00e1tica entre los alelos t y g de la mther y mtrr, respectivamente.  los niveles basales de folatos intraeritrocitarios no se hallan influenciados por los distintos genotipos. Sin embargo, durante el tratamiento con folatos, aquellos genotipos con la hcy elevada (tt dela mthfr y ff de la mtrr) acumularon menos folatos que los dem\u00e1s genotipos, debido posiblemente a un efecto de trampa de folatos.  el tratamiento con \u00e1cido isolevofol\u00ednico (5-formiltetrahifrofolato) produce una respuesta m\u00e1s eficaz que otras formas de folatos (tetrahidrofolato, 5-metiltetrahidrofolato) en la reducci\u00f3n de los niveles s\u00e9ricos de hcy, obsrv\u00e1ndose su efecto desde el 2\u00c2\u00ba d\u00eda de tratamiento y manteni\u00e9ndose  hasta 30 d\u00edas despu\u00e9s de finalizado el mismo.  los niveles intraeritrocitairos de folatos son un mejor indicador del status org\u00e1nico de esta vitamina que sus niveles s\u00e9ricos. As\u00ed, mientras los folatos s\u00e9ricos mantienen un dintel a pesar de seguir existiendo un aporte ex\u00f3geno, los eritrocitos siguen almancenando folatos en estas circunstancias.  la variante mutada gg del polimorfismo a66g de la mtrr conduce a un aumento de la hcy plasm\u00e1tica de mayor magnitud que la observada en el polimorfismo de la mthrf. Aunque el tratamiento con folatos disminuye de foram significativa los niveles de hcy s\u00e9rica, \u00e9stos son siempre estad\u00edsticamente superiores a los observados en los homocigotos salvajes aa y heterocigotos ag.  los niveles de homocisteina y folatos, relacionados directamente con m\u00faltiples patolog\u00edas, est\u00e1n asociados a los polimorfismos c677t de la mthfr y a66g de la mtrr. La respuesta de ambos par\u00e1metros al tratamiento<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Polimorfismos genicos del metabolismo de los folatos e influencia del tratamiento con \u00e1cido folico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Polimorfismos genicos del metabolismo de los folatos e influencia del tratamiento con \u00e1cido folico <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Hidalgo Vazquez Jos\u00e9 Miguel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 M\u00e1laga<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 29\/09\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Maximiliano Ruiz Galdon<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  anselmo Perea remujo <\/li>\n<li>pedro Aranda lara (vocal)<\/li>\n<li>Francisco Alba arag\u00ed\u00bcez (vocal)<\/li>\n<li>alfonso Rodriguez Martinez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Hidalgo Vazquez Jos\u00e9 Miguel Los niveles basales de hcy plasm\u00e1tica se encontraron elevados significativamente en el genotipo [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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