{"id":26006,"date":"2018-03-09T09:17:37","date_gmt":"2018-03-09T09:17:37","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/implicacion-monoaminergica-en-el-efecto-analgesico-y-antidepresivo-de-opiaceos-ata%c2%adpicos\/"},"modified":"2018-03-09T09:17:37","modified_gmt":"2018-03-09T09:17:37","slug":"implicacion-monoaminergica-en-el-efecto-analgesico-y-antidepresivo-de-opiaceos-ata%c2%adpicos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/implicacion-monoaminergica-en-el-efecto-analgesico-y-antidepresivo-de-opiaceos-ata%c2%adpicos\/","title":{"rendered":"Implicaci\u00f3n monoamin\u00e9rgica en el efecto analg\u00e9sico y antidepresivo de opi\u00e1ceos at\u00edpicos"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Rojas Corrales M. Olga <\/strong><\/h2>\n<p>Los sistemas opioide, serotonin\u00e9rgico y noradren\u00e9rgico est\u00e1n implicados tanto en los des\u00f3rdenes afectivos como en la nocicepci\u00f3n. Sin embargo, los f\u00e1rmacos opi\u00e1ceos son usados casi exclusivamente para el tratamiento del dolor. A su vez, la depresi\u00f3n es tratada casi exclusivamente con f\u00e1rmacos que act\u00faan sobre los sistemas monoamin\u00e9rgicos. Resulta parad\u00f3jico, en este sentido, que existan f\u00e1rmacos que combinan estos tres mecanismos y que, sin embargo, son usados exclusivamente en el tratamiento una de estas patolog\u00edas. este es el caso de determinados opi\u00e1ceos at\u00edpicos, tipo tramadol, que han demostrado ser capaces de inhibir la recaptaci\u00f3n de monoaminas y que se usan de manera casi exclusiva para el tratamiento del dolor.  estas propiedades monoamin\u00e9rgicas, que de manera  obvia participan en su efecto analg\u00e9sico, podr\u00edan conferir a este tipo de f\u00e1rmacos, o a sus derivados, propiedades a\u00f1adidas aprovechables desde el punto de vista cl\u00ednico. As\u00ed, estos compuestos opi\u00e1ceos capaces de inhibir la recaptaci\u00f3n de monoaminas parec\u00edan ser los candidatos ideales para estudiar una nueva aproximaci\u00f3n terap\u00e9utica en la regulaci\u00f3n de las conductas afectivas. Y adem\u00e1s, podr\u00edan tener as\u00ed un valor a\u00f1adido en su uso habitual, la terapia analg\u00e9sica, si actuaran sobre determinados componentes no som\u00e1ticos, sino afectivos, del dolor. El objetivo general de la presente tesis doctoral ha sido estudiar si las propiedades monoamin\u00e9rgicas de determinados f\u00e1rmacos opi\u00e1ceos, pudieran inducir un efecto tipo antidepresivo, y si estas propiedades participan de manera importante en su efecto opi\u00e1ceos, pudieran incluir un efecto tipo antidepresivo, y si estas propiedades participan de manera importante en su efecto analg\u00e9sico. Para ello, el estudio se ha dividido en dos partes bien definidas, cada una encaminada hacia un objetivo concreto.  objetivo 1  estudiar si diversos f\u00e1rmacos opi\u00e1ceos at\u00edpicos, con propiedades de inhibici<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Implicaci\u00f3n monoamin\u00e9rgica en el efecto analg\u00e9sico y antidepresivo de opi\u00e1ceos at\u00edpicos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Implicaci\u00f3n monoamin\u00e9rgica en el efecto analg\u00e9sico y antidepresivo de opi\u00e1ceos at\u00edpicos <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Rojas Corrales M. Olga <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00e1diz<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 30\/09\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Mic\u00f3 Segura Juan  Antonio<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Ana Mar\u00eda Navarro arevalo <\/li>\n<li>purificacion Tejedor real (vocal)<\/li>\n<li>mercedes Fern\u00e1ndez ar\u00e9valo (vocal)<\/li>\n<li>victor Perez sola (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rojas Corrales M. Olga Los sistemas opioide, serotonin\u00e9rgico y noradren\u00e9rgico est\u00e1n implicados tanto en los des\u00f3rdenes afectivos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1506,9,957,6530,183],"tags":[1744,54476,1866,75469,75468,60060],"class_list":["post-26006","post","type-post","status-publish","format-standard","hentry","category-cadiz","category-ciencias-medicas","category-farmacologia","category-farmacologia-experimental","category-farmacos-psicotropicos","tag-ana-maria-navarro-arevalo","tag-mercedes-fernandez-arevalo","tag-mico-segura-juan-antonio","tag-purificacion-tejedor-real","tag-rojas-corrales-m-olga","tag-victor-perez-sola"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/26006","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=26006"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/26006\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=26006"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=26006"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=26006"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}