{"id":26081,"date":"2003-01-10T00:00:00","date_gmt":"2003-01-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-los-efectos-de-la-coadministracion-de-dosis-bajas-del-factor-de-crecimiento-semejante-a-la-insulina-tipo-i-igf-i-e-interferon-alfa-2a-ifn-alfa2a-en-la-cirrosis-hepatica-experimental\/"},"modified":"2003-01-10T00:00:00","modified_gmt":"2003-01-10T00:00:00","slug":"estudio-de-los-efectos-de-la-coadministracion-de-dosis-bajas-del-factor-de-crecimiento-semejante-a-la-insulina-tipo-i-igf-i-e-interferon-alfa-2a-ifn-alfa2a-en-la-cirrosis-hepatica-experimental","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/malaga\/estudio-de-los-efectos-de-la-coadministracion-de-dosis-bajas-del-factor-de-crecimiento-semejante-a-la-insulina-tipo-i-igf-i-e-interferon-alfa-2a-ifn-alfa2a-en-la-cirrosis-hepatica-experimental\/","title":{"rendered":"Estudio de los efectos de la coadministraci\u00f3n de dosis bajas del factor de crecimiento semejante a la insulina tipo i (igf-i) e interferon alfa 2a (ifn alfa2a) en la cirrosis hep\u00e1tica experimental."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Federico Tutau G\u00f3mez <\/strong><\/h2>\n<p>La cirrosis hep\u00e1tica constituye una enfermedad de gran preValencia social para la que existen escasas posibilidades terap\u00e9uticas, constituyendo, en no pocos casos, el transplante hep\u00e1tico, el \u00fanico recurso disponible.  recientemente, el factor de crecimiento semejante a la insulina tipo i(igf-i) ha mostrado efectos beneficiosos en el tratamiento de la cirrosis hep\u00e1tica. por otro lado, est\u00e1 demostrado que interfer\u00f3n alfa 2a ejerce un efecto beneficioso en las hepatitis virales.  en el presente trabajo, en el que se indujo la cirrosis hep\u00e1tica experimental, por inhalaci\u00f3n de tetracloruro de carbono a ratas wistar macho, nos planteamos la coadministraci\u00f3n de ambos factores en el intento de ensayar una terapia m\u00e1s eficaz que la administraci\u00f3n de cada uno de ellos por separado. Para ello se han evaluado pruebas de funci\u00f3n hep\u00e1tica com\u00fanmente utilizadas en la pr\u00e1ctica cl\u00ednica habitual; el grado de peroxidaci\u00f3n lip\u00eddica en homogeneizados hep\u00e1ticos; y la histopatolog\u00eda. Los resultados muestran que con la combinaci\u00f3n de ambos factores, no s\u00f3lo se mantienen los efectos de cada uno de ellos por separado, sino que incluso se potencian, ejerciendo el combinado efectos anabolizante, antioxidante, antifibrog\u00e9nico y fibrol\u00edtico en el h\u00edgado cirr\u00f3tico, provocando en este una mejor\u00eda significativa en tan solo 21 d\u00edas de tratamiento.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de los efectos de la coadministraci\u00f3n de dosis bajas del factor de crecimiento semejante a la insulina tipo i (igf-i) e interferon alfa 2a (ifn alfa2a) en la cirrosis hep\u00e1tica experimental.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de los efectos de la coadministraci\u00f3n de dosis bajas del factor de crecimiento semejante a la insulina tipo i (igf-i) e interferon alfa 2a (ifn alfa2a) en la cirrosis hep\u00e1tica experimental. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Federico Tutau G\u00f3mez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 M\u00e1laga<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/10\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Inmaculada Castilla Cortazar<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: salvador Gonzalez baron <\/li>\n<li>vicente Carre\u00f1o Garc\u00eda (vocal)<\/li>\n<li> Herrer\u00edas guti\u00e9rrez Juan  Manuel (vocal)<\/li>\n<li>nicol\u00e1s Garc\u00eda gonz\u00e1lez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Federico Tutau G\u00f3mez La cirrosis hep\u00e1tica constituye una enfermedad de gran preValencia social para la que existen 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