{"id":26094,"date":"2003-01-10T00:00:00","date_gmt":"2003-01-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/factores-de-progresion-tumoral-en-el-sarcoma-de-kaposi-estudio-inmunohistoqua%c2%admico\/"},"modified":"2003-01-10T00:00:00","modified_gmt":"2003-01-10T00:00:00","slug":"factores-de-progresion-tumoral-en-el-sarcoma-de-kaposi-estudio-inmunohistoqua%c2%admico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/factores-de-progresion-tumoral-en-el-sarcoma-de-kaposi-estudio-inmunohistoqua%c2%admico\/","title":{"rendered":"Factores de progresi\u00f3n tumoral en el sarcoma de kaposi: estudio inmunohistoqu\u00edmico"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Rosa Mar\u00eda Penin Mosquera <\/strong><\/h2>\n<p>El sarcoma de kaposi (sk) es una enfermedad angioroliferativa t\u00edpicamente cut\u00e1nea, que tambi\u00e9n puede afectar a localizaciones extracut\u00e1neas. Se han descrito cuatro formas afectando a diferentes grupos epidemiol\u00f3gicos con rasgos cl\u00ednicos y evolutivos distintos: la cl\u00e1sica, la africana end\u00e9mica, la asociada a inmunosupresi\u00f3n y la asociada a sida. En la piel el sk se desarrolla en tres estadios histol\u00f3gicos evolutivos: m\u00e1cula, placa y tumor. en sus fases iniciales (m\u00e1cula\/placa) el sk se comporta como una hiperplasia reactiva, mientras que en las lesiones tumorales y extracut\u00e1neas muestra caracter\u00edsticas neopl\u00e1sicas. El sk se desarrolla en el contexto de la infecci\u00f3n por el herpes virus humano tipo 8 (hhv-8) y muestra una patogenia compleja en la que participan alteraciones en la red de citoquinas y factores de crecimiento angiog\u00e9nicos, como por ejemplo el factor de crecimiento hepatocitario (hgf) y su receptor c-met; y en las proteinas que controlan la proliferaci\u00f3n celular, como la p27kipi y la p45skp2, y tambi\u00e9n la apoptosis. La alteraci\u00f3n de estas mol\u00e9culas se ha descrito como factores de progresi\u00f3n en numerosos c\u00e1nceres humanos.  el objetivo de este trabajo es intentar demostrar si estas mol\u00e9culas est\u00e1n tambi\u00e9n impicadas en la patogenia del sk y si se comportan favoreciendo su progresi\u00f3n a estadios avanzados. Nuestros resultados indican que el hgf\/c-met y la p27kip1 act\u00faan como factores de progresi\u00f3n tumoral favoreciendo la evoluci\u00f3n de las lesiones cut\u00e1neas y la aparici\u00f3n de lesiones extracut\u00e1neas en el sk. La p45skp2, a trav\u00e9s de la degradaci\u00f3n de la p27kip1, parece favorecer tambi\u00e9n la progresi\u00f3n del sk, aunque los resultados indican que pueden existir otras mol\u00e9culas que tambi\u00e9n participan degradando a las p27kip1. Por tanto, nuestros resultados apoyan la naturaleza tumoral de las lesiones cut\u00e1neas avanzadas y extracut\u00e1neas del sk.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Factores de progresi\u00f3n tumoral en el sarcoma de kaposi: estudio inmunohistoqu\u00edmico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Factores de progresi\u00f3n tumoral en el sarcoma de kaposi: estudio inmunohistoqu\u00edmico <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Rosa Mar\u00eda Penin Mosquera <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/10\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Fern\u00e1ndez Figueras M. Teresa<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: celestino Rey-joly barroso <\/li>\n<li>joaqu\u00edn Marcoval caus (vocal)<\/li>\n<li>enrique Lerma puertas (vocal)<\/li>\n<li>ll\u00facia Al\u00f3s hern\u00e1ndez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rosa Mar\u00eda Penin Mosquera El sarcoma de kaposi (sk) es una enfermedad angioroliferativa t\u00edpicamente cut\u00e1nea, que tambi\u00e9n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[1492,44524,75669,20135,75670,75668],"class_list":["post-26094","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-celestino-rey-joly-barroso","tag-enrique-lerma-puertas","tag-fernandez-figueras-m-teresa","tag-joaquin-marcoval-caus","tag-llucia-alos-hernandez","tag-rosa-maria-penin-mosquera"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/26094","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=26094"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/26094\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=26094"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=26094"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=26094"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}