{"id":26095,"date":"2003-01-10T00:00:00","date_gmt":"2003-01-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/reconstitucion-de-productos-hematopoyeticos-criopreservados-control-de-calidad-estabilidad-osmotica-y-lavado-de-dmso\/"},"modified":"2003-01-10T00:00:00","modified_gmt":"2003-01-10T00:00:00","slug":"reconstitucion-de-productos-hematopoyeticos-criopreservados-control-de-calidad-estabilidad-osmotica-y-lavado-de-dmso","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/reconstitucion-de-productos-hematopoyeticos-criopreservados-control-de-calidad-estabilidad-osmotica-y-lavado-de-dmso\/","title":{"rendered":"Reconstituci\u00f3n de productos hematopoy\u00e9ticos criopreservados: control de calidad, estabilidad osm\u00f3tica y lavado de dmso"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Luciano Rodr\u00edguez G\u00f3mez <\/strong><\/h2>\n<p>La log\u00edstica de un trasplante de progenitores hematopoy\u00e9ticos (tph) incluye en la mayor\u00eda de casos (tph aut\u00f3logo y de sangre de cord\u00f3n umbilical (scu), una etapa de criopreservaci\u00f3n a temperaturas de -196\u00c2\u00bac. Las t\u00e9cnicas de congelaci\u00f3n m\u00e1s extendidas utilizan dmso como crioprotector para optimizar la viabilidad y funcionalidad de las c\u00e9lulas reduciendo la proporci\u00f3n de agua congelada y la deshidrataci\u00f3n intracelular durante el proceso de congelaci\u00f3n.  la presencia del crioprotector hace que las suspensiones celulares descongeladas sean hipert\u00f3nicas y como las c\u00e9lulas responden importando y exportando agua frente a un cambio de osmolaridad, el retorno a condiciones isot\u00f3nicas puede resultar en la superaci\u00f3n de los l\u00edmites mec\u00e1nicos de las membranas plasm\u00e1ticas por una entrada masiva de agua al citoplasma (choque osm\u00f3tico). este fen\u00f3meno es de especial importancia durante la reconstituci\u00f3n y manipulaci\u00f3n de c\u00e9lulas descongeladas debido a que la membrana celular es un conjunto de l\u00edpidos y prote\u00ednas organizados que por debajo de los 20\u00aac pierde fluidez, limitando su resistencia y por tanto su capacidad de respuesta osm\u00f3tica.  en 1978, el profesor john goldman95 public\u00f3 las primeras evidencias del fen\u00f3meno de choque osm\u00f3tico sobre la reducci\u00f3n de capacidad clonog\u00e9nica en m\u00e9dula \u00f3sea (mo) descongelada. Sin embargo, este trabajo no ha tenido una gran repercusi\u00f3n en los protocolos de criopreservaci\u00f3n seguramente porque el n\u00famero de c\u00e9lulas progenitoras hematopoy\u00e9ticas (cph) en mo y en af\u00e9resis (cph-a) est\u00e1 por encima de lumbral m\u00ednimo definido para uso cl\u00ednico. Esta situaci\u00f3n cambia en el momento que la sci se define como fuente de c\u00e9lulas progenitoras debido a su limitada proporci\u00f3n en estos productos. As\u00ed, en 1995 el dr. Pablo rubinstein139 reabre el debate de la relevancia del choque osm\u00f3tico en productos hematopoy\u00e9ticos descongelados e introduce la estabilidad osm\u00f3tica previa a la infusi<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Reconstituci\u00f3n de productos hematopoy\u00e9ticos criopreservados: control de calidad, estabilidad osm\u00f3tica y lavado de dmso<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Reconstituci\u00f3n de productos hematopoy\u00e9ticos criopreservados: control de calidad, estabilidad osm\u00f3tica y lavado de dmso <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Luciano Rodr\u00edguez G\u00f3mez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/10\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Miquel Rutllant Ba\u00f1eras<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: joan Garc\u00eda l\u00f3pez <\/li>\n<li>jordi Sierra gil (vocal)<\/li>\n<li>Alberto Gra\u00f1ena batista (vocal)<\/li>\n<li>isabel Badell serra (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Luciano Rodr\u00edguez G\u00f3mez La log\u00edstica de un trasplante de progenitores hematopoy\u00e9ticos (tph) incluye en la mayor\u00eda de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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