{"id":26103,"date":"2003-02-10T00:00:00","date_gmt":"2003-02-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/establecimiento-de-metodologa%c2%adas-anala%c2%adticas-para-la-separacion-y-caracterizacion-de-peptidos-y-protea%c2%adnas-de-interes-terapeutico\/"},"modified":"2003-02-10T00:00:00","modified_gmt":"2003-02-10T00:00:00","slug":"establecimiento-de-metodologa%c2%adas-anala%c2%adticas-para-la-separacion-y-caracterizacion-de-peptidos-y-protea%c2%adnas-de-interes-terapeutico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/barcelona\/establecimiento-de-metodologa%c2%adas-anala%c2%adticas-para-la-separacion-y-caracterizacion-de-peptidos-y-protea%c2%adnas-de-interes-terapeutico\/","title":{"rendered":"Establecimiento de metodolog\u00edas anal\u00edticas para la separaci\u00f3n y caracterizaci\u00f3n de p\u00e9ptidos y prote\u00ednas de inter\u00e9s terap\u00e9utico"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Fernando Juli\u00e1n Benavente Moreno <\/strong><\/h2>\n<p>El objetivo final de esta tesis doctoral ha sido el establecimiento de metodolog\u00edas anal\u00edticas para la separaci\u00f3n y caracterizaci\u00f3n de mezclas complejas de p\u00e9ptidos y prote\u00ednas de gran inter\u00e9s terap\u00e9utico, empleando para ello la cromatograf\u00eda de l\u00edquidos (lc) y la electroforesis capilar (ce) con detecci\u00f3n por espectrofotometr\u00eda ultravioleta (uv) y sus acomplamientos ala espectrometr\u00eda de masas (ms). Este objetivo principal engloba otros m\u00e1s concretos que se detallan a continuaci\u00f3n:  * desarrollar modelos que describan el comportamiento cromatogr\u00e1fico y electrofor\u00e9tico de sustancias pept\u00eddicas presentes en mezclas complejas, con la finalidad de poder predecir, a partir de un reducido n\u00famero de medidas experimentales, las condiciones para obtener una separaci\u00f3n \u00f3ptima de estos analitos. Se establecen dos tipos de modelos:  &#8211; modelos que explican el comportamiento cromatogr\u00e1fico de los analitos en funci\u00f3n de la polaridad de la fase m\u00f3vil.  &#8211; modelos que explican el comportamiento cromatogr\u00e1fico y electrofor\u00e9tico de los analitos ionizables en funci\u00f3n del ph de la fase m\u00f3vil cromatogr\u00e1fica o del electrolito utilizado para la serpaci\u00f3n electrofor\u00e9tica, las constantes de disociaci\u00f3n de los analitos estudiados y los coeficientes de actividad.  * determinar mediante los modelos anteriores los valores de pka, en medio acuoso o hidroorg\u00e1nico, de las sustancias analizadas.  * utilizar la cromatograf\u00eda de l\u00edquidos acoplada a la espectrometr\u00eda de masas con ionizaci\u00f3n por electrospray (lc-esi-ms) para la separaci\u00f3n y caracterizaci\u00f3n de las sustancias presentes en crudos de s\u00edntesis de hormonas pept\u00eddicas de gran inter\u00e9s terap\u00e9utico. Proponer las condiciones de separaci\u00f3n \u00f3pt\u00edmas para una posterior purificaci\u00f3n por lc a escala preparativa de la hormona pept\u00eddica sintetizada y para identificar las impurezas presentes en las mezclas.  * combinar la lc, la lc-esi-ms y la ce para profundizar en el an\u00e1lisi<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Establecimiento de metodolog\u00edas anal\u00edticas para la separaci\u00f3n y caracterizaci\u00f3n de p\u00e9ptidos y prote\u00ednas de inter\u00e9s terap\u00e9utico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Establecimiento de metodolog\u00edas anal\u00edticas para la separaci\u00f3n y caracterizaci\u00f3n de p\u00e9ptidos y prote\u00ednas de inter\u00e9s terap\u00e9utico <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Fernando Juli\u00e1n Benavente Moreno <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 02\/10\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jose Barbosa Torralbo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: gemma Rauret dalmau <\/li>\n<li>de Bol\u00f3s carme (vocal)<\/li>\n<li>Jos\u00e9 Luis G\u00f3mez ariza (vocal)<\/li>\n<li>lucas Hernandez hernandez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Fernando Juli\u00e1n Benavente Moreno El objetivo final de esta tesis doctoral ha sido el establecimiento de metodolog\u00edas 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