{"id":26111,"date":"2003-02-10T00:00:00","date_gmt":"2003-02-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/factores-pronosticos-en-sa%c2%adndromes-mielodisplasicos-leucemias-mieloides-agudas-secundarias-sdm-lma-s\/"},"modified":"2003-02-10T00:00:00","modified_gmt":"2003-02-10T00:00:00","slug":"factores-pronosticos-en-sa%c2%adndromes-mielodisplasicos-leucemias-mieloides-agudas-secundarias-sdm-lma-s","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/oviedo\/factores-pronosticos-en-sa%c2%adndromes-mielodisplasicos-leucemias-mieloides-agudas-secundarias-sdm-lma-s\/","title":{"rendered":"Factores pron\u00f3sticos en s\u00edndromes mielodispl\u00e1sicos. leucemias mieloides agudas secundarias (sdm\/lma-s)"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Beatriz Ordo\u00f1ez Fernandez <\/strong><\/h2>\n<p>El objetivo del estudio fue investigar, que variables diagn\u00f3sticas y evolutivas presentaban valor pron\u00f3stico indenpendiente en 86 smd\/lma-s. El estudio incluy\u00f3 52 mujeres y 34 varones con una mediana de edad de 63 a\u00f1os (16-85). 35\/86 presentaron smd previo y, de estos, 16 (18,6%) nunca desarrollaron lma. Tuvieron displasia trilineal (mdt) 32 (37,2%) y 48 (60,8%) multil\u00ednea. los smd m\u00e1s frecuentes fueron areb (42,8%) y areb-t(20%). Entre las lma: 11m0, 9ml, 16m2, 3m3, 3m4, 15m5, 8m6, 2m7, 1biofenot\u00edpica y 2 indiferenciadas. historia previa: 67 recibieron quimioterapia (qt) y\/o radioterapia (rt), 8 exposiciones ocupacional. 1 irradiaci\u00f3n, 3 inmunosupresores, 1 131i, 2 fueron tumores s\u00edncronos y 4 neoplasias tratadas con cirug\u00eda. Solo 16 pacientes presentaron cariotipo normal (n) y 70 (81%) anomal\u00edas citogen\u00e9ticas clonales. En 6, las anomalias eran de \u00abbuen pron\u00f3stico\u00bb (bp), 30 presentaban menos de 3 aberrraciones y 34 fueron cariotipos con cambios m\u00faltiples. los cariotipos bp coincidieron en el grupo que desarroll\u00f3 smd\/lma-s en un per\u00edodo inferior a 4 a\u00f1os tras la exposici\u00f3n al t\u00f3xico. 42 pacientes recibieron quimioterapia intensiva, 3 consolidaron con autotrasplante y 4 con tmo alog\u00e9nico. En 18 (42,9%) se obtuvo remisi\u00f3n completa (rc). De las variables analizadas, s\u00f3lo la ausencia de  blastos en sp (p=0,0174) y el cariotipo (p=0,0140) incidieron sobre la supervivencia total (st). el % de rc fue m\u00e1s elevado en los grupos citogen\u00e9ticos de mejor pron\u00f3stico (83,3 vs 36,1%,p=0,03). Una edad menor 40 a\u00f1os y\/o leucocitosis menos 20&#215;10 9\/l mostraron s\u00f3lo una probable significaci\u00f3n (p=0,0801;p=0,0596). El an\u00e1lisis multivariante permiti\u00f3 identificar el cariotipo bp y la ausencia de blastosis como factores pron\u00f3sticos independientes.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Factores pron\u00f3sticos en s\u00edndromes mielodispl\u00e1sicos. leucemias mieloides agudas secundarias (sdm\/lma-s)<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Factores pron\u00f3sticos en s\u00edndromes mielodispl\u00e1sicos. leucemias mieloides agudas secundarias (sdm\/lma-s) <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Beatriz Ordo\u00f1ez Fernandez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 02\/10\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Elisa Lu\u00f1o Fern\u00e1ndez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Arribas castrillo Jos\u00e9 manuel <\/li>\n<li>carmen Burgaleta alonso de ozalla (vocal)<\/li>\n<li>Andr\u00e9s Sampedro nu\u00f1o (vocal)<\/li>\n<li>Mar\u00eda  consuelo Juan a Del ca\u00f1izo fernandez roldan (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Beatriz Ordo\u00f1ez Fernandez El objetivo del estudio fue investigar, que variables diagn\u00f3sticas y evolutivas presentaban valor pron\u00f3stico [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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