{"id":26147,"date":"2003-03-10T00:00:00","date_gmt":"2003-03-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/farmacocinetica-poblacional-de-vancomicina-en-pacientes-con-neoplasias-hematologicas\/"},"modified":"2003-03-10T00:00:00","modified_gmt":"2003-03-10T00:00:00","slug":"farmacocinetica-poblacional-de-vancomicina-en-pacientes-con-neoplasias-hematologicas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/salamanca\/farmacocinetica-poblacional-de-vancomicina-en-pacientes-con-neoplasias-hematologicas\/","title":{"rendered":"Farmacocin\u00e9tica poblacional de vancomicina en pacientes con neoplasias hematol\u00f3gicas"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Herrera Huerta Emma Virginia <\/strong><\/h2>\n<p>El objetivo de la tesis fue estimar los par\u00e1metros farmacocin\u00e9ticos de vancomicina en pacientes con neoplasias hematol\u00f3gicas. Para ello se desarrollo un modelo poblacional general para vancomicina y uno espec\u00edfico para la subpoblaci\u00f3n de pacientes con leucemia mielobl\u00e1stica aguda, mediante la aplicaci\u00f3n de la metodolog\u00eda de efectos mixtos proporcionada por el programa nonmem.  se confirma que en esta poblaci\u00f3n el aclaramiento de vancomicina, aunque dependiente del funcionalismo renal del paciente, es significativamente m\u00e1s alto que en pacientes sin este tipo de patolog\u00edas. El volumen de distribuci\u00f3n presenta, asimismo, valores m\u00e1s elevados que los habituales y muestra \u00fanicamente dependencia del peso total del paciente.  la validaci\u00f3n de los modelos general y espec\u00edfico desarrollados, y su comparaci\u00f3n frente al considerado de referencia cl\u00ednica en nuestro pa\u00eds, indica la aplicabilidad y fiabilidad de los primeros, en contraposici\u00f3n al sesgo e inexactitud de este \u00faltimo, en cuanto a su capacidad predictiva a priori. no obstante, las diferencias se aten\u00faan al utilizar un algoritmo de estimaci\u00f3n bayesiana.  las modificaciones cin\u00e9ticas detectadas confirman resultados previos obtenidos con otro tipo de metodolog\u00edas y subrayan la necesidad de revisr al alza los criterios de dosificaci\u00f3n de vancomicina con el fin de optimizar la terapia en este tipo de pacientes. En consecuencia, se ha desarrollado una estrategia gr\u00e1fica, \u00fatil en la selecci\u00f3n de reg\u00edmenes de dosificaci\u00f3n \u00f3ptimos de acuerdo con criterios farmacocin\u00e9ticos y farmacodin\u00e1micos.  en definitiva, este estudio realizado en una amplia poblaci\u00f3n y con una metodolog\u00eda adecuada, viene a confirmar estudios previos realizados en este departamento y otros bibliogr\u00e1ficos que establecen una mayor capacidad de eliminaci\u00f3n y distribuci\u00f3n de algunos antibi\u00f3ticos como glucop\u00e9ptidos y aminoglic\u00f3sidos en pacientes con neoplasias hematol\u00f3gicas. El riesgo de<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Farmacocin\u00e9tica poblacional de vancomicina en pacientes con neoplasias hematol\u00f3gicas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Farmacocin\u00e9tica poblacional de vancomicina en pacientes con neoplasias hematol\u00f3gicas <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Herrera Huerta Emma Virginia <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 03\/10\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda  Del Mar Fernandez De Gatta Garcia<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: alfonso Jes\u00fas Dominguez gil hurle <\/li>\n<li>azucena Aldaz pastor (vocal)<\/li>\n<li> Calvo hern\u00e1ndez Mar\u00eda victoria (vocal)<\/li>\n<li>Mar\u00eda eugenia M\u00e9ndez esteban (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Herrera Huerta Emma Virginia El objetivo de la tesis fue estimar los par\u00e1metros farmacocin\u00e9ticos de vancomicina en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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