{"id":26151,"date":"2003-03-10T00:00:00","date_gmt":"2003-03-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/factores-implicados-en-la-variabilidad-interindividual-en-la-respuesta-a-metadona-analisis-farmacocinetico-farmacodinamico-poblacional\/"},"modified":"2003-03-10T00:00:00","modified_gmt":"2003-03-10T00:00:00","slug":"factores-implicados-en-la-variabilidad-interindividual-en-la-respuesta-a-metadona-analisis-farmacocinetico-farmacodinamico-poblacional","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/pais-vasco-euskal-herriko-unibertsitatea\/factores-implicados-en-la-variabilidad-interindividual-en-la-respuesta-a-metadona-analisis-farmacocinetico-farmacodinamico-poblacional\/","title":{"rendered":"Factores implicados en la variabilidad interindividual en la respuesta a metadona. analisis farmacocinetico-farmacodinamico poblacional."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Monica Rodriguez Calvo <\/strong><\/h2>\n<p>La metadona es un opi\u00e1ceo sint\u00e9tico que se ha venido usando durante a\u00f1os para suprimir los s\u00edntomas de abstinencia en los individuos con dependencia a otros opi\u00e1ceos, as\u00ed como en el tratamiento del dolor cr\u00f3nico. Sin embargo, se ha observado que tras la administraci\u00f3n de metadona a pacientes concretos, existe una gran variabilidad tanto inter como intraindividual en la dosis necesaria para producir el efecto deseado, dificultando as\u00ed la predicci\u00f3n de los reg\u00edmenes de dosificaci\u00f3n m\u00e1s adecuados.  se ha evaluado, en primer lugar, la analgesia producida por la metadona en ratas macho y ratas hembra y se ha indagado acerca de las causas de dicha variabilidad con un planteamiento farmacocin\u00e9tico\/farmacodin\u00e1mico global (estudo 1).  en una segunda parte, se ha evaluado (estudio 2) la farmacocin\u00e9tica y farmacodinamia de metadona administrada por v\u00eda intravenosa en ratas con niveles elevados de a-1-glicoprote\u00edna \u00e1cida, y consecuentemente del porcentaje de fijaci\u00f3n, provocados por dos situaciones:  a)  inflamaci\u00f3n experimental mediante la administraci\u00f3n de esencia de trementina, un agente ampliamente utilizado con este fin  b)  infusi\u00f3n intravenosa de a-1-glicoprote\u00edna \u00e1cida  los resultados del presente trabajo han puesto de manifiesto que existen dos factores implicados en la variabilidad en la respuesta de metadona: el sexo y los niveles de a-1-glicoprote\u00edna \u00e1cida. Las ratas hembra mostraron un menor efecto analg\u00e9sico, tras recibir la misma dosis de metadona que los machos, explicado principalmente por cambios en los par\u00e1metros farmacodin\u00e1micos. los animales con niveles elevados de a-1-glicoprote\u00edna \u00e1cida tambi\u00e9n mostraron menor efecto analg\u00e9sico que se explic\u00f3 de forma en el an\u00e1lisis integrado farmacocin\u00e9tico-farmacodin\u00e1mico.  la inclusi\u00f3n del grupo infusi\u00f3n en el estudio, ha permitido identificar a la a-1-glicoprote\u00edna \u00e1cida por s\u00ed misma, independiente del proceso de fijaci\u00f3n y de las patolog\u00eda<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Factores implicados en la variabilidad interindividual en la respuesta a metadona. analisis farmacocinetico-farmacodinamico poblacional.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Factores implicados en la variabilidad interindividual en la respuesta a metadona. analisis farmacocinetico-farmacodinamico poblacional. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Monica Rodriguez Calvo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 03\/10\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rosario Calvo Duo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Quintana loyola <\/li>\n<li>alfonso Moreno gonzalez (vocal)<\/li>\n<li>sergio Erill saez (vocal)<\/li>\n<li>victor Jimenez torrs (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Monica Rodriguez Calvo La metadona es un opi\u00e1ceo sint\u00e9tico que se ha venido usando durante a\u00f1os para [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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