{"id":26186,"date":"2003-06-10T00:00:00","date_gmt":"2003-06-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-cinetica-viral-en-pacientes-sometidos-a-dos-pautas-de-tratamiento-triple-correlacion-entre-medidas-de-arn-viral-y-antigeno-c-en-suero\/"},"modified":"2003-06-10T00:00:00","modified_gmt":"2003-06-10T00:00:00","slug":"estudio-de-cinetica-viral-en-pacientes-sometidos-a-dos-pautas-de-tratamiento-triple-correlacion-entre-medidas-de-arn-viral-y-antigeno-c-en-suero","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/a-coruna\/estudio-de-cinetica-viral-en-pacientes-sometidos-a-dos-pautas-de-tratamiento-triple-correlacion-entre-medidas-de-arn-viral-y-antigeno-c-en-suero\/","title":{"rendered":"Estudio de cin\u00e9tica viral en pacientes sometidos a dos pautas de tratamiento triple. correlaci\u00f3n entre medidas de arn viral y antigeno c en suero"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Lorenzo L\u00f3pez Jos\u00e9 \u00e1ngel <\/strong><\/h2>\n<p>Objetivos  determinar en una poblaci\u00f3n aut\u00f3ctona la utilidad del uso de un ciclo previo de inducci\u00f3n con interfer\u00f3n al tratamiento triple con interfer\u00f3n, amantadina y ribavirina para lograr una r\u00e1pida negativaci\u00f3n de la carga viral y describir la posterior evoluci\u00f3n de la viremia. Estudiar la correlaci\u00f3n entre los distintos medios de monitorizaci\u00f3n de la carga viral como predictor precoz de respuesta o de ausencia de la misma.  dise\u00f1o  estudio de cohortes. Se incluyeron 16 pacientes en dos grupos (inducci\u00f3n + triple terapia o solo inducci\u00f3n) criterios de inclusi\u00f3n, exclusi\u00f3n y seguimiento seg\u00fan consensus nih.  resultados  68.57% var\u00f3n, edad media 44,4 a\u00f1os. El tiempo medio de infecci\u00f3n 10 a\u00f1os. 18.75% genotipo la 18,75% 2a\/2c, 12.5% 3a y 50% 1b. Carga viral basal 5.82 +- 4.3 logs ui\/ml. Se hall\u00f3 la pendiente de la recta de regresi\u00f3n grupo a:  no respondedores: para los dos primeros d\u00edas del tratamiento es -0.22 +- 0.78 y en respondedores es de -1.88 +- 3.6. Diferencia significativa p menor 0.055. Grupo b: no respondedores: -0.29 +- 1.53 y en respondedores -0.33 +- 0.21.Respondedores con recidiva es de -0.17 +- 0.2 y en respuesta sostenida es de -0.46 +- 0.6. En todos los grupos la pendiente tiene 0 a lo largo del tratamiento. El coeficiente de correlaci\u00f3n entre nitr\u00f3geno c y rna viral calculado para el total de las muestras fue de 0.887 (entre 0.943 y 0.781 para una p menor 0.01); todo el rango se encuentra dentro de la significaci\u00f3n para p menor 0.01. El coeficiente de correlaci\u00f3n para cada uno de los rangos descritos fue de 0.157, -0.129, 0.41, 0.669, 0.321. existe una diferencia significativa entre los valores correspondientes al intervalo entre 5 y 5.45 logs sin que esa diferencia se observe entre los otros rangos establecidos. La correlaci\u00f3n calculada para cada genotipo es de: 3a: 0.72-0.98, 1a: 0.79-0.94 y 2a\/2c 0.5-0.95. Se observa una diferencia significativa entre la correlaci\u00f3n observada en los<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de cin\u00e9tica viral en pacientes sometidos a dos pautas de tratamiento triple. correlaci\u00f3n entre medidas de arn viral y antigeno c en suero<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de cin\u00e9tica viral en pacientes sometidos a dos pautas de tratamiento triple. correlaci\u00f3n entre medidas de arn viral y antigeno c en suero <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Lorenzo L\u00f3pez Jos\u00e9 \u00e1ngel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 A coru\u00f1a<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 06\/10\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda  De Los \u00e1ngeles Castro Iglesias<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 manuel Martinez vazquez <\/li>\n<li>ram\u00f3n P\u00e9rez \u00e1lvarez (vocal)<\/li>\n<li>ricardo Moreno otero (vocal)<\/li>\n<li> L\u00f3pez calvo Mar\u00eda  soledad (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Lorenzo L\u00f3pez Jos\u00e9 \u00e1ngel Objetivos determinar en una poblaci\u00f3n aut\u00f3ctona la utilidad del uso de un ciclo [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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