{"id":26238,"date":"2003-10-10T00:00:00","date_gmt":"2003-10-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-de-la-migracion-y-la-forma-celular-durante-el-desarrollo-de-drosophila-melanogaster-papel-de-las-integrinas\/"},"modified":"2003-10-10T00:00:00","modified_gmt":"2003-10-10T00:00:00","slug":"regulacion-de-la-migracion-y-la-forma-celular-durante-el-desarrollo-de-drosophila-melanogaster-papel-de-las-integrinas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-de-la-migracion-y-la-forma-celular-durante-el-desarrollo-de-drosophila-melanogaster-papel-de-las-integrinas\/","title":{"rendered":"Regulaci\u00f3n de la migraci\u00f3n y la forma celular durante el desarrollo de drosophila melanogaster: papel de las integrinas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Paloma Dominguez Gimenez <\/strong><\/h2>\n<p>Durante el desarrollo de los organismos multiceluares tienen lugar diversos procesos entre los que cabe destacar aquellos que implican un cambio en la forma de las c\u00e9lulas, ya que pueden afectar a la funcionalidad del tejido adulto. Para que estos cambios tengan lugar de forma correcta, las c\u00e9lulas deben reorganizar su citoesqueleto y regular sus sistemas de adhesi\u00f3n celular. las integrinas son receptores de superficie celular que median adhesi\u00f3n a la matriz extracelular y al mismo tiempo pueden contactar con el interior celular. En esta tesis hemos analizado la implicaci\u00f3n de las integrinas en los cambios de forma celular que tienen lugar durante el desarrollo.  el proceso de formaci\u00f3n del ala es uno de los cambios de forma m\u00e1s dram\u00e1ticos del desarrollo de drosophila melanogaster, en que una monocapa epitelial se pliega sobre s\u00ed misma para dar la bicapa que es el ala adulta. Estudios previos han demostrado que durante le proceso de formaci\u00f3n del ala, la eliminaci\u00f3n de la matriz extracelular basal en el primordio de ala conduce un cambio en la forma del epitelio que acelera el desarrollo del ala. Sin embargo, se desconoc\u00eda c\u00f3mo cambios en el exterior celular pod\u00edan ser transmitidos al interior. En esta tesis doctoral se demuestra por primera vez que las integrinas, por su habilidad de mediar adhesi\u00f3n a la matriz y al mismo tiempo contactar con prote\u00ednas del citoplasma celular, transmiten cambios del exterior al interior celular durante el desarrollo. Adem\u00e1s, demostramos que las integrinas regulan los cambios de forma celular necesarios para que la morfog\u00e9nesis de ala tenga lugar correctamente. Asimismo, proponemos un sistema de regulaci\u00f3n din\u00e1mica de la actividad de la integrinas durante la morfog\u00e9nesis del ala, a trav\u00e9s de la rutura de ras\/raf.  otro tipo de cambio de forma celular implica la migraci\u00f3n de una o varias c\u00e9lulas. Las integrinas est\u00e1n implicadas en la migraci\u00f3n de diversos sistemas epiteliales tanto<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Regulaci\u00f3n de la migraci\u00f3n y la forma celular durante el desarrollo de drosophila melanogaster: papel de las integrinas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Regulaci\u00f3n de la migraci\u00f3n y la forma celular durante el desarrollo de drosophila melanogaster: papel de las integrinas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Paloma Dominguez Gimenez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/10\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda Dolores Mart\u00edn Bermudo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: gines Morata perez <\/li>\n<li>ernesto S\u00e1nchez-herrero arbide (vocal)<\/li>\n<li>jordi Casanova roca (vocal)<\/li>\n<li>acaimo Gonz\u00e1lez reyes (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Paloma Dominguez Gimenez Durante el desarrollo de los organismos multiceluares tienen lugar diversos procesos entre los que [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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