{"id":26240,"date":"2003-10-10T00:00:00","date_gmt":"2003-10-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/expresion-de-inos-en-un-modelo-de-enfermedad-inflamatoria-intestinal-en-ratas\/"},"modified":"2003-10-10T00:00:00","modified_gmt":"2003-10-10T00:00:00","slug":"expresion-de-inos-en-un-modelo-de-enfermedad-inflamatoria-intestinal-en-ratas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/expresion-de-inos-en-un-modelo-de-enfermedad-inflamatoria-intestinal-en-ratas\/","title":{"rendered":"Expresi\u00f3n de inos en un modelo de enfermedad inflamatoria intestinal en ratas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Arturo Luis Colon Rodriguez <\/strong><\/h2>\n<p>En la enfermedad inflamatoria intestinal se ha demostrado un incremento en la expresi\u00f3n y actividad de la isoforma inducible de la \u00f3xido n\u00edtrico sintasa (inos). De igual forma existe un incremento de los niveles de tnf-alfa activo. Utilizando un modelo experimental de colitis en rata inducida por el \u00e1cido trinitrobenc\u00e9nico (tnbs), intentamos determinar si la interacci\u00f3n farmacol\u00f3gica en la v\u00eda metab\u00f3lica del no mediante el empleo bien de inhibidores espec\u00edficos de inos (1400w), bien de inhibidores del enzima convertidora de tnf-alfa (tace) (bb-1101; o-fenantrolina) logra una mejor\u00eda del proceso inflamatorio. Hemos demostrado que la inhibici\u00f3n farmacol\u00f3gica de la s\u00edntesis de no en nuestro modelo de colitis, ya sea de forma directa o impidiendo la formaci\u00f3n de tnf-alfa activo, logra una mejor\u00eda del proceso inflamatorio demostrada mediante la realizaci\u00f3n de estudios macrosc\u00f3picos, histol\u00f3gicos y bioqu\u00edmicos. Nuestros datos abren la posibilidad de una nueva v\u00eda terap\u00e9utica en la enfermedad inflamatoria intestinal.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Expresi\u00f3n de inos en un modelo de enfermedad inflamatoria intestinal en ratas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Expresi\u00f3n de inos en un modelo de enfermedad inflamatoria intestinal en ratas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Arturo Luis Colon Rodriguez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/10\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ignacio Lizacuain Hernandez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pedro Lorenzo fern\u00e1ndez <\/li>\n<li>marisabel Mourelle mencini (vocal)<\/li>\n<li>Jos\u00e9 Rodrigo garcia (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Arturo Luis Colon Rodriguez En la enfermedad inflamatoria intestinal se ha demostrado un incremento en la expresi\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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