{"id":26298,"date":"2018-03-09T09:18:03","date_gmt":"2018-03-09T09:18:03","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regeneracion-neuronal-en-el-nucleo-arcuato-en-respuesta-a-lesion-excitotoxica-estudio-de-la-proliferacion-celular\/"},"modified":"2018-03-09T09:18:03","modified_gmt":"2018-03-09T09:18:03","slug":"regeneracion-neuronal-en-el-nucleo-arcuato-en-respuesta-a-lesion-excitotoxica-estudio-de-la-proliferacion-celular","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/salamanca\/regeneracion-neuronal-en-el-nucleo-arcuato-en-respuesta-a-lesion-excitotoxica-estudio-de-la-proliferacion-celular\/","title":{"rendered":"Regeneraci\u00f3n neuronal en el nucleo arcuato en respuesta a lesion excitotoxica. estudio de la proliferaci\u00f3n celular."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carolina Dimey Galindo <\/strong><\/h2>\n<p>Tras la destrucci\u00f3n producida por la administraci\u00f3n de glutamato, se produce un proceso de reparaci\u00f3n y regeneraci\u00f3n en el n\u00facleo arcuato del hipot\u00e1lamo. este proceso incluye la repoblaci\u00f3n parcial del n\u00facleo por nuevas neuronas as\u00ed como una gliosis reactiva de larga duraci\u00f3n. Hip\u00f3tesis: planteamos que tanto las nuevas neuronas como buena parte de los astrocitos reacitvos se originan por proliferaci\u00f3n a partir de c\u00e9lulas progenitoras multipotenciales que podr\u00edan situarse en las paredes ventriculares de la zona lesionada (tercer ventr\u00edculo). Objetivos: 1) avanzar en el conocimiento de los mecanismos de regeneraci\u00f3n en el sistema nervioso central de mam\u00edferos in vivo. 1a) cuantificar el proceso de regeneraci\u00f3n. Para ello contaremos los n\u00facleos que incorporen brdu en toda la extensi\u00f3n rostrocaudal del territorio lesionado; 1b) analizar la posible proliferaci\u00f3n celular en el territorio del n\u00facleo arcuato y la eminencia media; 1c) dilucidar el destino de las c\u00e9lulas que han proliferado estableciendo su relaci\u00f3n con la repoblaci\u00f3n neuronal o la gliosis reactiva. Resultados y conclusiones: en las ratas control la proliferaci\u00f3n detectable es muy escasa, despu\u00e9s de la lesi\u00f3n la proliferaci\u00f3n celular se incrementa de manera extraordinaria en relaci\u00f3n con la observada en los animales control. En el ep\u00e9ndimo sorprende la permanencia e intensidad de la reacci\u00f3n a la bromodesoxiuridina, incluso en las ratas tratadas de treinta d\u00edas de vida. Este hecho indica que las c\u00e9lulas ependimarias abandonan r\u00e1pidamente el cilco de divisi\u00f3n celular pasando a un estado de reposo. la mayor\u00eda de dichas c\u00e9lulas son tanicitos y son los mejores candidatos para constituir una reserva de c\u00e9lulas stem neurales que abandonan su estado quiescente en respuesta a la lesi\u00f3n. La mayor\u00eda de las c\u00e9lulas que proliferaron contienen prote\u00edna glial fibrilar \u00e1cida, lo que demuestra el importante papel de la proliferaci\u00f3n en la respuesta glial.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Regeneraci\u00f3n neuronal en el nucleo arcuato en respuesta a lesion excitotoxica. estudio de la proliferaci\u00f3n celular.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Regeneraci\u00f3n neuronal en el nucleo arcuato en respuesta a lesion excitotoxica. estudio de la proliferaci\u00f3n celular. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carolina Dimey Galindo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/10\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Efren Pastor Jimenez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Santiago Rodr\u00edguez Garc\u00eda <\/li>\n<li>isabel San Jos\u00e9 crespo (vocal)<\/li>\n<li>M\u00aa \u00e1ngeles D\u00edez s\u00e1nchez (vocal)<\/li>\n<li>Francisco Coll\u00eda fern\u00e1ndez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carolina Dimey Galindo Tras la destrucci\u00f3n producida por la administraci\u00f3n de glutamato, se produce un proceso de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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