{"id":26300,"date":"2018-03-09T09:18:04","date_gmt":"2018-03-09T09:18:04","guid":{"rendered":""},"modified":"2018-03-09T09:18:04","modified_gmt":"2018-03-09T09:18:04","slug":"influencia-del-polimorfismo-del-gen-de-la-eca-apo-e-y-del-receptor-beta-3-adrenergico-sobre-el-perfil-lipidico-la-resistencia-a-la-insulina-y-la-composicion-lipa%c2%addica-de-la-membrana-en-la-hipe","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sevilla\/influencia-del-polimorfismo-del-gen-de-la-eca-apo-e-y-del-receptor-beta-3-adrenergico-sobre-el-perfil-lipidico-la-resistencia-a-la-insulina-y-la-composicion-lipa%c2%addica-de-la-membrana-en-la-hipe\/","title":{"rendered":"Influencia del polimorfismo del gen de la eca, apo-e y del receptor beta-3 adrenergico sobre el perfil lipidico, la resistencia a la insulina y la composici\u00f3n lip\u00eddica de la membrana, en la hipertensi\u00f3n arterial de reciente comienzo"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 Salvador Garcia Morillo <\/strong><\/h2>\n<p>Encontramos diferencias en el riesgo cardiovascular en funci\u00f3n del sexo de la poblaci\u00f3n hipertensa. As\u00ed los varones hipertensos de nuestra poblaci\u00f3n mostraban un perf\u00edl lip\u00eddico mucho m\u00e1s aterog\u00e9nico, con mayor grado de resistencia a la insulina medida por homa y mayor actividad del  contratansporte sodio\/litio. Esta diferencia del riesgo cardiovascular puede ser debido a una mayor preValencia del alelo e4 de la apolipoproteina e entre los hipertensos varones. Contrariamente, las mujeres presentaban una mayor proporci\u00f3n del alelo e2 de la apo-e. Respecto al polimorfismo i\/d del gen de la eca, en nuestra poblaci\u00f3n de hipertensos de reciente comienzo, el genotipo ii se asoci\u00f3 a la presencia de resistencia a ala insulina, expresado por unas cifras de pad m\u00e1s elevadas y a mayores niveles de glucemia basal entre los varones. A pesar de esta asociaci\u00f3n, el genotipo dd del gen de la eca fu mucho mas prevalente entre las mujeres hipertensa que eran obesas (imc mayor 30). Sin embargo, no encontramos asociaci\u00f3n entre este polimorfismo y el s\u00edndrome metab\u00f3lico, el perfil lip\u00eddico, la actividad del contra ni en la composici\u00f3n lip\u00eddica de la membrana.  no pudimos demostrar que el polimorfismo arg64trp del receptor beta-3 adren\u00e9rgico se relacionase con mayores cifras de pa ni con los valores de imc en hipertensos. tampoco tuvo influencia sobre la presencia de resistencia a la insulina ni sobre la composici\u00f3n lip\u00eddica de membrana. Si parece que la presencia de la mutaci\u00f3n entre los varones da lugar a un perfil lip\u00eddico m\u00e1s desfavorable con unos niveles superiores de ldl-c, tg y un \u00edndice aterog\u00e9nico m\u00e1s elevado; relaci\u00f3n que no encontramos entre las mujeres.  definitivamente parece que el alelo e4 del gen de la apolipoproteina e se asocia fuertemente con un perfil lip\u00eddico muy aterog\u00e9nico, niveles superiores de apoproteinas y lipoprote\u00edna (a) respecto al resto de genotipos. Este riesgo cardiovascular desfavorable se acomp<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Influencia del polimorfismo del gen de la eca, apo-e y del receptor beta-3 adrenergico sobre el perfil lipidico, la resistencia a la insulina y la composici\u00f3n lip\u00eddica de la membrana, en la hipertensi\u00f3n arterial de reciente comienzo<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Influencia del polimorfismo del gen de la eca, apo-e y del receptor beta-3 adrenergico sobre el perfil lipidico, la resistencia a la insulina y la composici\u00f3n lip\u00eddica de la membrana, en la hipertensi\u00f3n arterial de reciente comienzo <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 Salvador Garcia Morillo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Sevilla<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/10\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Villar Ortiz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Castillo ferrando Juan  ram\u00f3n <\/li>\n<li>joaqu\u00edn Carneado de la fuente (vocal)<\/li>\n<li>Francisco Gomez rodriguez (vocal)<\/li>\n<li>federico Casimiro soriguer escofet (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 Salvador Garcia Morillo Encontramos diferencias en el riesgo cardiovascular en funci\u00f3n del sexo de la poblaci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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