{"id":26346,"date":"2018-03-09T09:18:07","date_gmt":"2018-03-09T09:18:07","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/adherencia-de-cepas-de-e-coli-en-pacientes-con-cirrosis-en-relacion-al-factor-de-resistencia-a-quinolonas\/"},"modified":"2018-03-09T09:18:07","modified_gmt":"2018-03-09T09:18:07","slug":"adherencia-de-cepas-de-e-coli-en-pacientes-con-cirrosis-en-relacion-al-factor-de-resistencia-a-quinolonas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/adherencia-de-cepas-de-e-coli-en-pacientes-con-cirrosis-en-relacion-al-factor-de-resistencia-a-quinolonas\/","title":{"rendered":"Adherencia de cepas de e.coli en pacientes con cirrosis, en relaci\u00f3n al factor de resistencia a quinolonas"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Gasc\u00f3n Ros M. Isabel <\/strong><\/h2>\n<p>El norfloxacino es una fluorquinolona de uso freceunte en la descontaminaci\u00f3n intestinal selectiva en pacientes con cirrosis hep\u00e1tica, como profilaxis secundaria de la peritonitis bacteriana espont\u00e1nea. Debido a su utilizaci\u00f3n prolongada, este hecho favorece la aparici\u00f3n de cepas de e.Coli resistentes a quinolonas en heces. Sin embargo, en estos pacientes del desarrollo de episodios infecciosos por este tipo de bacterias, no es tan frecuente como cabr\u00eda esperar, debido, probablemente, a la alteraci\u00f3n de la capacidad de adherencia a las c\u00e9lulas epiteliales intestinales inducida por el norfloxacino.  el objetivo principal de nuestro proyecto fue estudiar in vitro la capacidad de adherencia bacteriana a c\u00e9lulas epiteliales de las cepas de e.Coli aisladas en pacientes con cirrois, tanto en presencia como en ausencia de concentraciones subinhibidoras de norfloxacino en el medio, y valorar as\u00ed la utilidad del tratamiento prolongado con esta quinolona. Adem\u00e1s se evalu\u00f3 la presencia de tres de los factores de adherencia m\u00e1s importantes y su influencia en la adherencia al epiteli\u00f3.  se estudiaron 59 cepas de e.Coli (22 resistentes y 37 sensibles a quinolonas) obtenidas mediante escobillado rectal en pacientes con cirrosis, que se incubaron con c\u00e9lulas epiteliales bucales, con y sin concentraciones subinhibidoras de norfloxacino en el medio. La presencia de los tres factores de adherencia: fimbrias tipo i, adhesina afimbrial e intimina, se estudi\u00f3 mediante reacci\u00f3n en cadena de la polimerasa.  Ambos fenotipos bacterianos mostraron una capacidad de adherencia similar. Esta capacidad de adherencia a su vez, disminuy\u00f3 significativamente en todos los casos al a\u00f1adir concentraciones subinhibidoras de norfloxacino al medio. La presencia de factores de adherencia bacteriana fue menos frecuente en las cepas resistentes a quinolonas que en las sensibles. El 18% de las cepas analizadas en su conjunto carecieron de los factores de adherenci<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Adherencia de cepas de e.coli en pacientes con cirrosis, en relaci\u00f3n al factor de resistencia a quinolonas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Adherencia de cepas de e.coli en pacientes con cirrosis, en relaci\u00f3n al factor de resistencia a quinolonas <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Gasc\u00f3n Ros M. Isabel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/10\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Virginia Merino SanJuan<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: marina Herraez dominguez <\/li>\n<li>Carlos Guarner aguilar (vocal)<\/li>\n<li>Miguel Perez mateo regadera (vocal)<\/li>\n<li>matilde Merino sanJuan (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gasc\u00f3n Ros M. Isabel El norfloxacino es una fluorquinolona de uso freceunte en la descontaminaci\u00f3n intestinal selectiva [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[64035,76248,3310,17020,11374,12062],"class_list":["post-26346","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-carlos-guarner-aguilar","tag-gascon-ros-m-isabel","tag-marina-herraez-dominguez","tag-matilde-merino-sanjuan","tag-miguel-perez-mateo-regadera","tag-virginia-merino-sanjuan"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/26346","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=26346"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/26346\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=26346"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=26346"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=26346"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}