{"id":26348,"date":"2018-03-09T09:18:08","date_gmt":"2018-03-09T09:18:08","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/contribucion-al-estudio-de-los-modelos-in-vivo-in-vitro-en-investigacion-farmaco-onco-endocrinologica-y-su-repercusion-sore-la-reduccion-del-uso-de-animales-en-investigacion\/"},"modified":"2018-03-09T09:18:08","modified_gmt":"2018-03-09T09:18:08","slug":"contribucion-al-estudio-de-los-modelos-in-vivo-in-vitro-en-investigacion-farmaco-onco-endocrinologica-y-su-repercusion-sore-la-reduccion-del-uso-de-animales-en-investigacion","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/zaragoza\/contribucion-al-estudio-de-los-modelos-in-vivo-in-vitro-en-investigacion-farmaco-onco-endocrinologica-y-su-repercusion-sore-la-reduccion-del-uso-de-animales-en-investigacion\/","title":{"rendered":"Contribuci\u00f3n al estudio de los modelos in vivo in vitro en investigaci\u00f3n f\u00e1rmaco-onco-endocrinol\u00f3gica y su repercusi\u00f3n sore la reducci\u00f3n del uso de animales en investigaci\u00f3n"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mauricio Redondo Muller <\/strong><\/h2>\n<p>La reducci\u00f3n del n\u00famero de animales en investigaci\u00f3n es un proceso continuo e inevitable, que viene marcado por un cambio en la sociedad de los pa\u00edses mas industrialmente desarrollados y ratificado por los legisladores tanto a nivel nacional como a nivel internacional por la promulgaci\u00f3n de leyes cada vez mas restrictivas en el uso de animales con fines experimentales. a pesar de que hoy en d\u00eda las t\u00e9cnicas de biolog\u00eda celular y molecular tienen un importante papel, el uso de animales continua siendo una referencia en el desarrollo farmacol\u00f3gico de una nueva sustancia.  en el presente trabajo, se ha realizado el an\u00e1lisis y comparaci\u00f3n entre modelos in vitro y ensayos in vivo, con los objetivos de determinar si los m\u00e9todos in vitro pueden reproducir los resultados obtenidos in vivo, desarrollar un programa de desarrollo in vitro que permita predecir los  mejores modelos a desarrollar in vivo, y evaluar la reducci\u00f3n en tiempo, materiales y n\u00famero de animales utilizados.  el poder predictivo de los modelos in vitro por separado es muy limitado, observ\u00e1ndose un alto nivel de falsos positivos. La valoraci\u00f3n conjunta y de forma relacionada de todas las t\u00e9cnicas in vitro realizadas, conduce a una significativa reducci\u00f3n del tiempo (48%), materiales (58%), y \u00e9l n\u00famero de animales (64%) en el desarrollo de un determinado proyecto, indicando que si bien no es posible sustituir el uso de aniamles si que lleva a una mejor relaci\u00f3n costes\/objetivos. Destacando el m\u00e9todo de fibra hueca como el mas adecuado para la valoraci\u00f3n del poder terap\u00e9utico en sustancias con un mecanismo de acci\u00f3n indirecto.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Contribuci\u00f3n al estudio de los modelos in vivo in vitro en investigaci\u00f3n f\u00e1rmaco-onco-endocrinol\u00f3gica y su repercusi\u00f3n sore la reducci\u00f3n del uso de animales en investigaci\u00f3n<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Contribuci\u00f3n al estudio de los modelos in vivo in vitro en investigaci\u00f3n f\u00e1rmaco-onco-endocrinol\u00f3gica y su repercusi\u00f3n sore la reducci\u00f3n del uso de animales en investigaci\u00f3n <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mauricio Redondo Muller <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Zaragoza<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/10\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Morales Lamuela M. Rosa<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ana Ferrer dufol <\/li>\n<li> G\u00f3mez lechon m. Jos\u00e9 (vocal)<\/li>\n<li>thomas Reissman (vocal)<\/li>\n<li>adela Lopez de cerain salsamendi (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mauricio Redondo Muller La reducci\u00f3n del n\u00famero de animales en investigaci\u00f3n es un proceso continuo e inevitable, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[13610],"tags":[32121,76254,76255,76252,76253,76256],"class_list":["post-26348","post","type-post","status-publish","format-standard","hentry","category-zaragoza","tag-adela-lopez-de-cerain-salsamendi","tag-ana-ferrer-dufol","tag-gomez-lechon-m-jose","tag-mauricio-redondo-muller","tag-morales-lamuela-m-rosa","tag-thomas-reissman"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/26348","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=26348"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/26348\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=26348"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=26348"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=26348"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}