{"id":26368,"date":"2018-03-09T09:18:09","date_gmt":"2018-03-09T09:18:09","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/los-esferoides-multicelulares-como-test-predictivo-de-radiosensibilidad-y-radiocurabilidad-tumoral\/"},"modified":"2018-03-09T09:18:09","modified_gmt":"2018-03-09T09:18:09","slug":"los-esferoides-multicelulares-como-test-predictivo-de-radiosensibilidad-y-radiocurabilidad-tumoral","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/los-esferoides-multicelulares-como-test-predictivo-de-radiosensibilidad-y-radiocurabilidad-tumoral\/","title":{"rendered":"Los esferoides multicelulares como test predictivo de radiosensibilidad y radiocurabilidad tumoral"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Manuel Aranda Haro <\/strong><\/h2>\n<p>El empleo de test predictivos antes y durante el tratamiento con radioterapia del c\u00e1ncer de mama hormonodependiente podr\u00eda ayudar a clasificar a los pacientes en funci\u00f3n de la susceptibilidad individual a cada maniobra terap\u00e9utica y estos significar\u00eda una reducci\u00f3n importante de la yatrogenia.  la radiosensibilidad intr\u00ednseca de un tumor se estima mediante la medida de la fracci\u00f3n de superviviencia a 2 gy.  en esta tesis doctoral se propone como hip\u00f3tesis que la poblaci\u00f3n tumoral cambia en el curso del tratamiento por la influencia de factores como la reoxigenaci\u00f3n, regeneraci\u00f3n, reparaci\u00f3n y redistribuci\u00f3n en el ciclo celular de los clon\u00f3genos por lo que la estimaci\u00f3n puntual de la radiosensibilidad a 2 gy previa al tratamiento podr\u00eda resultar insuficiente.  para el estudio de la hip\u00f3tesis se ha utilizado el modelo tumoral de esferoides multicelulares de c\u00e1ncer de mama mcf 7 con el fin de alcanzar los siguientes objetivos:  1,- desarrollar un test de radiosensibilidad in vitro con objeto de estimar los par\u00e1metros de radiosensibilidad celular tumoral.  2,- establecer las condiciones de cultivo \u00f3ptimas en las que evaluar el efecto de la radiaci\u00f3n ionizante, administrada en dosis \u00fanica y fraccionada, sobre los esteroides multicelulares mcf 7.  3,- investigar el efecto de las modificaciones de la cin\u00e9tica de proliferaci\u00f3n celular provocada por el tratamiento hormonal y antihormonal sobre la respuesta a la radiaci\u00f3n de los esferoides multicelulares.  con el an\u00e1lisis de los resultados se han  obtenido las siguientes conclusiones:  1,- el modelo de esferoides multicelulares tiene unas cualidades respecto a conformaci\u00f3n globulas de las c\u00e9lulas y sus n\u00facleos, contacto intercelular y distribuci\u00f3n en el ciclo mit\u00f3tico celular y aporte de ox\u00edgeno y nutrientes que lo hace similar a los primeros estadios del desarrollo turmoral in vivo.  2,- al igual que para el cultivo en monocapa el antiestr\u00f3geno tamoxifeno<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Los esferoides multicelulares como test predictivo de radiosensibilidad y radiocurabilidad tumoral<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Los esferoides multicelulares como test predictivo de radiosensibilidad y radiocurabilidad tumoral <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Manuel Aranda Haro <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/10\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mercedes Villalobos Torres<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Zaragoza rubira Juan  ram\u00f3n <\/li>\n<li>lourdes De la pe\u00f1a fern\u00e1ndez (vocal)<\/li>\n<li>Mar\u00eda  rosario fatima Olea serrano (vocal)<\/li>\n<li> N\u00fa\u00f1ez torres Mar\u00eda isabel (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Manuel Aranda Haro El empleo de test predictivos antes y durante el tratamiento con radioterapia del c\u00e1ncer [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[76234,76299,3789,72526,76300,10778],"class_list":["post-26368","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-lourdes-de-la-pena-fernandez","tag-manuel-aranda-haro","tag-maria-rosario-fatima-olea-serrano","tag-mercedes-villalobos-torres","tag-nunez-torres-maria-isabel","tag-zaragoza-rubira-juan-ramon"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/26368","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=26368"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/26368\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=26368"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=26368"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=26368"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}