{"id":26394,"date":"2018-03-09T09:18:12","date_gmt":"2018-03-09T09:18:12","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/una-nueva-familia-de-peptidos-con-estructura-glumatil-tripeptido-amida-identificacion-y-actividad-biologica\/"},"modified":"2018-03-09T09:18:12","modified_gmt":"2018-03-09T09:18:12","slug":"una-nueva-familia-de-peptidos-con-estructura-glumatil-tripeptido-amida-identificacion-y-actividad-biologica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/murcia\/una-nueva-familia-de-peptidos-con-estructura-glumatil-tripeptido-amida-identificacion-y-actividad-biologica\/","title":{"rendered":"Una nueva familia de p\u00e9ptidos con estructura glumatil-trip\u00e9ptido amida. identificaci\u00f3n y actividad biol\u00f3gica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Antonio  Jose Ruiz Alcaraz <\/strong><\/h2>\n<p>Se estudi\u00f3 en test\u00edculo y plasma de p\u00e9ptidos relacionados con los p\u00e9ptidos trh-like. Para ello se usaron diversas t\u00e9cnicas cromatogr\u00e1ficas en serie (cromatograf\u00edas de exclusi\u00f3n en gel, de intercambio i\u00f3nico y hplc) que permitian purificar y caracterizar la estructura de los p\u00e9ptidos end\u00f3genos estudiados. Para confirmar dicha estructura se usaron t\u00e9cnicas de espectrometr\u00eda de masas molecular de tipo fab y de elecytrospay y trampa i\u00f3nica, con y sin fragmentaci\u00f3n. Estas t\u00e9cnicas permitieron la identificaci\u00f3n de una nueva familia de p\u00e9ptidos naturales end\u00f3genos presentes en el test\u00edculo y que aparecen en la sangre circulante. Esta familia presenta una estructura gen\u00e9rica de glutamil-trip\u00e9ptido amida (glu-x-pro amida). A su vez, se han carcterizado precursores biosint\u00e9ticos de algunos de los glutamil-tripeptidos amidados.  una vez realizado el estudio bioqu\u00edmico, pasamos al estudio de la actividad biol\u00f3gica de los distintos p\u00e9ptidos de estructura glutamil-trip\u00e9ptido amida demostrandose, por primera vez, su actividad como reguladores del eje hipofisario-gonadal, inhibiendo la liberaci\u00f3n de testosterona en unos casos y estimul\u00e1ndola en otros. La inhibici\u00f3n de la liberaci\u00f3n de testosterona iba acompa\u00f1ada, en todos los casos, de una inhibici\u00f3n espec\u00edfica de la hormona luteotropa (lh) sin modificaci\u00f3n de la hormona foliculoestimulante (fsh). Se pone de manifiesto que la inhibici\u00f3n de la liberaci\u00f3n de testosterona que algunos de los glutamil-trip\u00e9ptidos amidadados produce, se lleva a cabo a nivel hipofisario inhibiendo la liberaci\u00f3n lh de forma espec\u00edfica (efecto endocrino), mientras que la estimulaci\u00f3n provocada por otros p\u00e9ptidos glutamil-trip\u00e9ptidos amidados se realiza a nivel local en el test\u00edculo sin modificaciones ni en los niveles de lh, ni en los de fsh (efecto paracrino o autocrino).  teniendo en cuenta la estructura de los p\u00e9ptidos (glutamil-trip\u00e9ptido amida), el origen tisular y la actividad b<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Una nueva familia de p\u00e9ptidos con estructura glumatil-trip\u00e9ptido amida. identificaci\u00f3n y actividad biol\u00f3gica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Una nueva familia de p\u00e9ptidos con estructura glumatil-trip\u00e9ptido amida. identificaci\u00f3n y actividad biol\u00f3gica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Antonio  Jose Ruiz Alcaraz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/10\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Rio Garcia Jes\u00fas Del<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Brugger auban arturo jose <\/li>\n<li>Francisco Jos\u00e9 Morales olivas (vocal)<\/li>\n<li> Serrano molina Jos\u00e9 s. (vocal)<\/li>\n<li>Rafael Pe\u00f1afiel garcia (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Antonio Jose Ruiz Alcaraz Se estudi\u00f3 en test\u00edculo y plasma de p\u00e9ptidos relacionados con los p\u00e9ptidos trh-like. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[8235],"tags":[76363,43700,8313,25178,76364,54041],"class_list":["post-26394","post","type-post","status-publish","format-standard","hentry","category-murcia","tag-antonio-jose-ruiz-alcaraz","tag-brugger-auban-arturo-jose","tag-francisco-jose-morales-olivas","tag-rafael-penafiel-garcia","tag-rio-garcia-jesus-del","tag-serrano-molina-jose-s"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/26394","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=26394"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/26394\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=26394"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=26394"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=26394"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}