{"id":26413,"date":"2018-03-09T09:18:13","date_gmt":"2018-03-09T09:18:13","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-los-antiinflamatorios-no-esteroideos-sobre-la-actividad-de-aminopeptidasas-en-celulas-en-cultivo\/"},"modified":"2018-03-09T09:18:13","modified_gmt":"2018-03-09T09:18:13","slug":"efecto-de-los-antiinflamatorios-no-esteroideos-sobre-la-actividad-de-aminopeptidasas-en-celulas-en-cultivo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-los-antiinflamatorios-no-esteroideos-sobre-la-actividad-de-aminopeptidasas-en-celulas-en-cultivo\/","title":{"rendered":"Efecto de los antiinflamatorios no esteroideos sobre la actividad de aminopeptidasas en c\u00e9lulas en cultivo"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Gema Lucena Aguilar <\/strong><\/h2>\n<p>Las aminopeptidasas son enzimas proteol\u00edticos que catalizan la hidr\u00f3lisis de residuos aminoac\u00eddicos localizados en el extremo amino terminal. Enzimas que parecen desempe\u00f1ar un gran n\u00famero de funciones entre las que se encuentran, la actuaci\u00f3n en el proceso inflamatorio mediante la degradaci\u00f3n de ciertos neurop\u00e9tpidos que intervienen en dicho fen\u00f3meno. En relaci\u00f3n con la participaci\u00f3n de las aminopepetidasas en el fen\u00f3meno inflamatorio, hemos de se\u00f1alar que entre los f\u00e1rmacos usados para combatir tanto sus signos y s\u00edntomas se encuentran los antiinflamatorios no esteroideso o aines. Grupo que presenta claras diferencias con respecto al otro gran grupo de analg\u00e9sicos como son los opioides. Puesto que se conoce la participaci\u00f3n de las aminopeptidasas en los fen\u00f3menos \u00e1lgidos e inflamatorios, dos de los principales efectos terap\u00e9uticos que producen los aines, nos preguntamos si este tipo de f\u00e1rmacos con conocida capacidad para inhibir la s\u00edntesis de prostaglandinas, ejerc\u00edan alg\u00fan efecto sobre la actividad aminopeptid\u00e1sica. Por tanto los objetivos de la presente tesis fueron:  1,- determinar el perfil de actividad de aminopeptidasa en dos poblaciones celulares diferentes: osteoblastos humanos y c\u00e9lulas jeg.  2,- estudiar el efecto que algunos antiinflamatorios no esteroideos ejerc\u00edan sobre dicha actividad enzim\u00e1tica.  en nuestros resultados observamos que los aines ejerc\u00edan un efecto inhibidor sobre la actividad aminopeptid\u00e1sica, por lo que a la vista de ello, pudimos concluir que los aines pueden ejercer algunos de sus efectos farmacol\u00f3gicos o adversos a trav\u00e9s de la inhibici\u00f3n de dichan actividad aminopeptid\u00e1sica.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de los antiinflamatorios no esteroideos sobre la actividad de aminopeptidasas en c\u00e9lulas en cultivo<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de los antiinflamatorios no esteroideos sobre la actividad de aminopeptidasas en c\u00e9lulas en cultivo <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Gema Lucena Aguilar <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/10\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Alba Araguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Ramirez sanchez <\/li>\n<li>Luis Casis s\u00e1enz (vocal)<\/li>\n<li>candela Reyes botella (vocal)<\/li>\n<li>Juan Mugica garay (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gema Lucena Aguilar Las aminopeptidasas son enzimas proteol\u00edticos que catalizan la hidr\u00f3lisis de residuos aminoac\u00eddicos localizados en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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