{"id":26417,"date":"2018-03-09T09:18:14","date_gmt":"2018-03-09T09:18:14","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estrategias-de-simplificacion-en-el-tratamiento-de-la-infeccion-por-el-vih\/"},"modified":"2018-03-09T09:18:14","modified_gmt":"2018-03-09T09:18:14","slug":"estrategias-de-simplificacion-en-el-tratamiento-de-la-infeccion-por-el-vih","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estrategias-de-simplificacion-en-el-tratamiento-de-la-infeccion-por-el-vih\/","title":{"rendered":"Estrategias de simplificaci\u00f3n en el tratamiento de la infecci\u00f3n por el vih"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Pablo Barreiro Garcia <\/strong><\/h2>\n<p>Las combinaciones de dos inhibidores de la transcriptasa inversa y un inhibidor de la proteasa fueron las primeras en demostrar potencia antiviral capaz de producir beneficios cl\u00ednicos en pacientes infectados por el vih. Como contrapartida, en a\u00f1os posteriores se ha comprobado que dichos tratamientos pueden ver comprometida su eficacia a largo plazo por la aparici\u00f3n de efectos adversos o por la propia complejidad de su posolog\u00eda.  la aparici\u00f3n de nuevos f\u00e1rmacos antirretrovirales ha permitido dise\u00f1ar reg\u00edmenes sin inhibidores de la proteasas que, siendo a veces menos potentes que los primeros, son capaces de mantener suprimida la replicaci\u00f3n viral con igual o mayor eficacia.  en un primer estudio, de un total de 257 pacientes en tratamiento con un inhibidor de la proteasas y dos nucle\u00f3sidos inhibidores de la transcriptasa inversa, 127 siguieron con el mismo r\u00e9gimen y 130 pasaron a recibir los mismos nucle\u00f3sidos junto con un no-nucle\u00f3sido, la nevirapina. Tras 48 semanas de seguimiento, la eficacia virol\u00f3gica e inmunol\u00f3gica fue comparable en las dos ramas.  la rama de inhibidores de la proteasa present\u00f3 mayor incidencia de efectos adversos y mala adherencia. En la rama de nevirapina se demostr\u00f3 mejor\u00eda de los trastornos lip\u00eddicos y morfol\u00f3gicos.  el segundo estudio eval\u00faa el paso de reg\u00edmenes triples a la asociaci\u00f3n de hidroxiurea m\u00e1s didanosina. Un total de 187 pacientes pasaron de reg\u00edmenes triples a hidroxiurea m\u00e1s didanosina, de los cuales algo m\u00e1s de la mitad matuvieron la viremia controlada al final de las 48 semanas de seguimiento. las probabilidades de \u00e9xito virol\u00f3gico fueron mayores en pacientes con acm\u00e9 de carga viral bajo, nadir de linfocitos cd4+ alto y sin exposici\u00f3n previa a didanosina. Se observ\u00f3 un significativo descenso de linfocitos cd4+, no acompa\u00f1ado de eventos oportunistas. Los trastornos lip\u00eddicos y morfol\u00f3gicos mejoraron significativamente. La combinaci\u00f3n result\u00f3 bien tolerada,<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estrategias de simplificaci\u00f3n en el tratamiento de la infecci\u00f3n por el vih<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estrategias de simplificaci\u00f3n en el tratamiento de la infecci\u00f3n por el vih <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Pablo Barreiro Garcia <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/10\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Vicente Soriano Vazquez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: arturo Fernandez cruz <\/li>\n<li>Santiago Moreno guillen (vocal)<\/li>\n<li>Jos\u00e9 Mar\u00eda Pe\u00f1a  sanchez de rivera (vocal)<\/li>\n<li>Manuel Leal noval (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Pablo Barreiro Garcia Las combinaciones de dos inhibidores de la transcriptasa inversa y un inhibidor de la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[723,15497,42307,76417,24488,35000],"class_list":["post-26417","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-arturo-fernandez-cruz","tag-jose-maria-pena-sanchez-de-rivera","tag-manuel-leal-noval","tag-pablo-barreiro-garcia","tag-santiago-moreno-guillen","tag-vicente-soriano-vazquez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/26417","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=26417"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/26417\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=26417"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=26417"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=26417"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}