{"id":26423,"date":"2018-03-09T09:18:14","date_gmt":"2018-03-09T09:18:14","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/complicaciones-pulmonares-del-trasplante-de-progenitores-hematopoyeticos-en-pacientes-pediatricos\/"},"modified":"2018-03-09T09:18:14","modified_gmt":"2018-03-09T09:18:14","slug":"complicaciones-pulmonares-del-trasplante-de-progenitores-hematopoyeticos-en-pacientes-pediatricos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/complicaciones-pulmonares-del-trasplante-de-progenitores-hematopoyeticos-en-pacientes-pediatricos\/","title":{"rendered":"Complicaciones pulmonares del trasplante de progenitores hematopoy\u00e9ticos en pacientes pedi\u00e1tricos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ra\u00fal Alonso Riofr\u00edo <\/strong><\/h2>\n<p>Pacientes y m\u00e9todo  se revisan retrospectivamente las complicaciones pulmonares tempranas y tard\u00edas de 287 pacientes que recibieron trasplante de progenitores hematopoy\u00e9ticos (179 aut\u00f3logos y 108 alog\u00e9nicos). En los pacientes que presentaron una funci\u00f3n pulmonar pretrasplante normal y permanecieron libres de complicaciones pulmonares durante 2 a\u00f1os de seguimiento, se analiza propsectivametne la evoluci\u00f3n de los par\u00e1metros de funci\u00f3n pulmonar.  resultados  tras el trasplante alog\u00e9nico, 23 pacientes (21%) presentaron s\u00edndrome de hipoxia aguda (sha) (hipoxemia con sat o2 menor 90% y\/o presencia de signos cl\u00ednicos de dificultad respiratoria y\/o infiltrados pulmonares en la radiograf\u00eda de t\u00f3rax) en los 100 primeros d\u00edas posttrasplante. El inicio del cuadro ocurri\u00f3 de forma dispersa entre los 100 primeros d\u00edas, 17 (73,9%) de ellos precisaron ingreso en uci y hubo 10 fallecimientos (43,5%). Encontramos relaci\u00f3n con significaci\u00f3n estad\u00edstica entre la existencia de eich agudo (32,3% con eich vs 4,7% sin eich, p=0,01), el uso de donantes hla diferentes (42,8% con hla id\u00e9nticos, 10,9% con hla id\u00e9nticos, p=0,02) y la aparici\u00f3n del s\u00edndrome.  tras el trasplante aut\u00f3logo, 43 pacientes (24%) presentaron sha. El momento de aparici\u00f3n fue en todos los casos antes de los 20 d\u00edas posttrasplante, 15 (35%) precisaron ingreso en uci y hubo 11 fallecimientos (25,6%). Treinta y dos (74,4%) de los casos de sha fueron debidos a sha periinjerto (ocurren en los 3 d\u00edas en torno al injerto leucocitario y presentan fiebre mayor de 38,3\u00c2\u00bac de etiolog\u00eda no identificada), 3 de ellos presentaron hemorragia alveolar. Encontramos relaci\u00f3n con significaci\u00f3n entre haber sido acondicionado con busulfan (24% busulfan vs 7,1% otros, p=0,023) y la aparici\u00f3n de sha periinjerto.  las complicaciones tard\u00edas cr\u00f3nicas fueron definidas como aquellas que presentan s\u00edntomas respiratorios durante m\u00e1s de 4 meses y no responden al tratamiento. Los di<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Complicaciones pulmonares del trasplante de progenitores hematopoy\u00e9ticos en pacientes pedi\u00e1tricos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Complicaciones pulmonares del trasplante de progenitores hematopoy\u00e9ticos en pacientes pedi\u00e1tricos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ra\u00fal Alonso Riofr\u00edo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/10\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Villa Asensi Jos\u00e9 Ram\u00f3n<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Hern\u00e1ndez rodr\u00edguez <\/li>\n<li>Jos\u00e9 Luis Alvarez sala walther (vocal)<\/li>\n<li>isabel Badell serra (vocal)<\/li>\n<li>Rafael Fern\u00e1ndez-delgado cerd\u00e1 (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ra\u00fal Alonso Riofr\u00edo Pacientes y m\u00e9todo se revisan retrospectivamente las complicaciones pulmonares tempranas y tard\u00edas de 287 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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