{"id":26424,"date":"2018-03-09T09:18:14","date_gmt":"2018-03-09T09:18:14","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-molecular-de-anta%c2%adgenos-de-taenia-solium-t-saginata-relevantes-en-el-inmunodiagnostico-de-cisticercosis\/"},"modified":"2018-03-09T09:18:14","modified_gmt":"2018-03-09T09:18:14","slug":"caracterizacion-molecular-de-anta%c2%adgenos-de-taenia-solium-t-saginata-relevantes-en-el-inmunodiagnostico-de-cisticercosis","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-molecular-de-anta%c2%adgenos-de-taenia-solium-t-saginata-relevantes-en-el-inmunodiagnostico-de-cisticercosis\/","title":{"rendered":"Caracterizaci\u00f3n molecular de ant\u00edgenos de taenia solium\/t. saginata relevantes en el inmunodiagn\u00f3stico de cisticercosis"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Elizabeth Ferrer Jes\u00fas <\/strong><\/h2>\n<p>La cisticercosis es la infecci\u00f3n parasitaria producida por la larva o cisticero de taenia solium, afecta principalmente al sistema nervioso central causando neurocisticercosis (ncc). El inmunodiagn\u00f3stico es de gran importancia para detectar esta patolog\u00eda, aunque presenta limitaciones en cuanto a sensibilidad y especificidad. Teniendo en cuenta este problema, el objetivo de trabajo fue la caracterizaci\u00f3n y evaluaci\u00f3n de las propiedades diagn\u00f3sticas de ant\u00edgenos de oncosferas y metacestodos de taenia solium\/t. Saginata a trav\u00e9s del cribado dirigido de genotecas de expresi\u00f3n de dichos estados. Se caracterizaron los genes de t.Solium correspondientes a una prote\u00edna de choque t\u00e9rmico de bajo peso molecular (clon h11b), un ant\u00edgeno principal de tegumetno (clon h17g), y un ant\u00edgeno de exreci\u00f3n\/secreci\u00f3n de bajo peso molecular (clon m13h), adem\u00e1s se buscaron en las genotecas otros miembros relacionados a m13h mediante pcr y se obtuvieron 2 ant\u00edgenos nuevos b1 y m4. Tambi\u00e9n se estudiaron ant\u00edgenos de t.Saginata previamente clonados como paramiosina, ant\u00edgeno principal de oncosferas (hp6) y los p\u00e9ptidos sint\u00e9ticos tovis1, tovis5, hp6-3,teg-1, cow-10, derivados de ant\u00edgenos protectores.  todos los genes se expresaron en sistemas procariotas y adem\u00e1s b1 y hp6 en el sistema baculovirus. Se evaluaron las propiedades diagn\u00f3sticas de todos los ant\u00edgenos meidante elisa para ello se emplearon sueros de pacientes con cisticercosis confirmada (activa e inactiva) y con diagn\u00f3stico probable de cisticercosis, con parasitosis relacinadas y controles negativos, as\u00ed como tambi\u00e9n l\u00edquidos c\u00e9falo-raqu\u00eddeos (lcr) y sueros porcinos provenientes de cerdos infectados y sanos.  adem\u00e1s, los p\u00e9ptidos sint\u00e9ticos se evaluaron con sueros bovinos. Todos los ant\u00edgenos recombinantes estudiados mostraron una elevada sensiblidad en los pacientes con ncc activa a excepci\u00f3n de h17g. En esta fase el mejor ant\u00edgeno fue b1, independientemente del<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n molecular de ant\u00edgenos de taenia solium\/t. saginata relevantes en el inmunodiagn\u00f3stico de cisticercosis<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n molecular de ant\u00edgenos de taenia solium\/t. saginata relevantes en el inmunodiagn\u00f3stico de cisticercosis <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Elizabeth Ferrer Jes\u00fas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/10\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Teresa Garate Ormaechea<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Mar\u00eda (secretario) Requena rolan\u00eda <\/li>\n<li> Parkhouse r. michael e. (vocal)<\/li>\n<li>Jorge Alvar ezquerra (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Elizabeth Ferrer Jes\u00fas La cisticercosis es la infecci\u00f3n parasitaria producida por la larva o cisticero de taenia [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[76430,22232,76431,76432,23919],"class_list":["post-26424","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-elizabeth-ferrer-jesus","tag-jorge-alvar-ezquerra","tag-jose-maria-secretario-requena-rolania","tag-parkhouse-r-michael-e","tag-teresa-garate-ormaechea"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/26424","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=26424"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/26424\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=26424"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=26424"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=26424"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}