{"id":26439,"date":"2018-03-09T09:18:16","date_gmt":"2018-03-09T09:18:16","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-de-los-inhibidores-de-la-fosfodiesterasa-5-en-la-reactividad-de-los-vasos-del-pene\/"},"modified":"2018-03-09T09:18:16","modified_gmt":"2018-03-09T09:18:16","slug":"efectos-de-los-inhibidores-de-la-fosfodiesterasa-5-en-la-reactividad-de-los-vasos-del-pene","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-de-los-inhibidores-de-la-fosfodiesterasa-5-en-la-reactividad-de-los-vasos-del-pene\/","title":{"rendered":"Efectos de los inhibidores de la fosfodiesterasa 5 en la reactividad de los vasos del pene"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Marta Peiro Signes <\/strong><\/h2>\n<p>La arteria dorsal y la vena dorsal profunda del pene son los principales vasos de aporte y drenaje sangu\u00edneo al pene. En los \u00faltimos a\u00f1os, se han empleado los inhibidores de la fosfodiesterasa 5 y en concreto el sildenafilo, para el tratamiento de la disfunci\u00f3n er\u00e9ctil, si bien sus efectos a nivel de la vascularizaci\u00f3n del pene no son conocidos. En este este trabajo se plantearon los siguientes objetivos:  * estudio de los efectos del sildenafilo y zaprinast sobre arterias y venas del pene previamente contradias con noradrenalina y su influencia sobre la relajaci\u00f3n inducida por el nitroprusiato s\u00f3dico, un donante de \u00f3xido n\u00edtrico.  * determinar si los inhibidores de la fosfodiesterasa 5 pueden modificar la respuesta contr\u00e1ctil y relajante de estos vasos al est\u00edmulo neur\u00f3geno.  las muestras proced\u00edan de 26 donantes multiorg\u00e1nicos. Los segmentos se montaron en un ba\u00f1o de \u00f3rganos para su posterior registro de tensi\u00f3n isom\u00e9trica.  el sildenafilo y el zaprinast producen relajaci\u00f3n del m\u00fasculo liso vascular por mantener los niveles de gmpc impidiendo su degradaci\u00f3n. Esta relajaci\u00f3n es independiente de la producci\u00f3n de \u00f3xido n\u00edtrico.  el est\u00edmulo neur\u00f3geno adren\u00e9rgico es uno de los responsables del proceso de detumescencia. El sildenafilo y el zaprinast inhiben el est\u00edmulo neur\u00f3geno adren\u00e9rgico, por lo que favorecen el mantenimiento de la erecci\u00f3n.  la relajaci\u00f3n neur\u00f3gena no adren\u00e9rgica no colin\u00e9rgica (nitr\u00e9rgica) es muy potente en estos vasos debido a la gran contribuci\u00f3n del \u00f3xido n\u00edtrico en la erecci\u00f3n. Sildenafilo y zaprinast aumentan la relajaci\u00f3n nitr\u00e9rgica lo que permite a los vasos peneamos adaptarse al incremento del flujo sangu\u00edneo durante la erecci\u00f3n.  la incubaci\u00f3n con sildenafilo o zaprinast potenci\u00f3 la respuesta relajante al nitroprusiato s\u00f3dico, por lo que el uso conjunto de ambos f\u00e1rmacos puede considerarse como factor de riesgo de desarrollar hipotensi\u00f3n.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos de los inhibidores de la fosfodiesterasa 5 en la reactividad de los vasos del pene<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos de los inhibidores de la fosfodiesterasa 5 en la reactividad de los vasos del pene <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Marta Peiro Signes <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/10\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Vila Salinas Jos\u00e9 M.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: salvador Lluch lopez <\/li>\n<li>Javier Romero g\u00f3mez (vocal)<\/li>\n<li>Juan  bautista Martinez leon (vocal)<\/li>\n<li> Llopis borr\u00e1s Juan  Francisco (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Marta Peiro Signes La arteria dorsal y la vena dorsal profunda del pene son los principales vasos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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