{"id":26460,"date":"2018-03-09T09:18:17","date_gmt":"2018-03-09T09:18:17","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/factores-epidemiologicos-y-cla%c2%adnicos-y-receptor-cannabionoide-cb1-en-la-enfermedad-de-parkinson-esporadica\/"},"modified":"2018-03-09T09:18:17","modified_gmt":"2018-03-09T09:18:17","slug":"factores-epidemiologicos-y-cla%c2%adnicos-y-receptor-cannabionoide-cb1-en-la-enfermedad-de-parkinson-esporadica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/factores-epidemiologicos-y-cla%c2%adnicos-y-receptor-cannabionoide-cb1-en-la-enfermedad-de-parkinson-esporadica\/","title":{"rendered":"Factores epidemiol\u00f3gicos y cl\u00ednicos y receptor cannabionoide cb1 en la enfermedad de parkinson espor\u00e1dica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Francisco Barrero Hernandez <\/strong><\/h2>\n<p>En la enfermedad de parkinson a\u00fan no conocemos la etiolog\u00eda, seg\u00fan los \u00faltimos estudios es cada vez m\u00e1s importante la influencia de la gen\u00e9tica en su etiopatogenia. Con nuestro trabajo pretendemos establecer una relaci\u00f3n entre algunas variables fenot\u00edpicas de la enfermedad de parkinson(ep) con la presencia de alg\u00fan factor de riesgo gen\u00e9tico de car\u00e1cter modificante, la presencia de polimorfismos largos o cortos del gen cnr1 que codifica el receptor cannabinoide cb1.  se han recogido una serie de variables demogr\u00e1ficas, factores de riesgo y antecedentes neuropsicol\u00f3gicos en un grupo control con patolog\u00eda osteoarticular aguda\/cr\u00f3nica y en un grupo con enfermedad de parkinson espor\u00e1dica. Se realiz\u00f3 la valoraci\u00f3n cl\u00ednica de la enfermedad de parkinson, recogiendo variables en relaci\u00f3n al inicio de la enfermedad, evoluci\u00f3n, tratamiento realizado, complicaciones motoras, valoraci\u00f3n cl\u00ednica mediante escalas: updrs, hamilton, folstein, hoehm-yahr, schwab-england. Gen\u00e9ticamente se obtuvieron la presencia de alelos de acuerdo con la clasificaci\u00f3n de comings y cols. 1997, clasificando la muestra en dos genotipos: sujetos con los dos alelos grances (mayor = 5) o sujetos con al menos alg\u00fan alelo corto (mayor 5).  los datos se analizaron comparando las proporciones mediante chi-cuadrado y\/o test exacto de fisher y las medias mediante muestras no param\u00e9tricas u de mann-whitney. Tambi\u00e9n se realiz\u00f3 an\u00e1lisis multivariante mediante regresi\u00f3n log\u00edstica teniendo en cuenta las odd-ratio.  los resultados fueron los siguientes:  datos epidemiol\u00f3gicos: obtuvimos mayor proporci\u00f3n de paciente con canas en el grupo con ep, mayor proporci\u00f3n de pacientes con ep y depresi\u00f3n frente al grupo control.  \u00ed\u00aan el grupo de ep se relaciono la mayor evoluci\u00f3n de la enfermedad e incapacidad con la presencia de depresi\u00f3n, as\u00ed como mayor proporci\u00f3n de complicaciones motoras (discinesias\/fluctuaciones) en pacientes con ep de m\u00e1s evloci\u00f3n<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Factores epidemiol\u00f3gicos y cl\u00ednicos y receptor cannabionoide cb1 en la enfermedad de parkinson espor\u00e1dica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Factores epidemiol\u00f3gicos y cl\u00ednicos y receptor cannabionoide cb1 en la enfermedad de parkinson espor\u00e1dica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Francisco Barrero Hernandez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/10\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Blas Morales Gordo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Ramirez sanchez <\/li>\n<li>Jos\u00e9 Manuel Rodr\u00edguez ferrer (vocal)<\/li>\n<li>victor Campos arillo (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Francisco Barrero Hernandez En la enfermedad de parkinson a\u00fan no conocemos la etiolog\u00eda, seg\u00fan los \u00faltimos estudios [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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