{"id":26512,"date":"2018-03-09T09:18:21","date_gmt":"2018-03-09T09:18:21","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/aproximacion-a-la-sa%c2%adntesis-de-quasinoides-pentaca%c2%adclicos-a-partir-de-acidos-comunicos\/"},"modified":"2018-03-09T09:18:21","modified_gmt":"2018-03-09T09:18:21","slug":"aproximacion-a-la-sa%c2%adntesis-de-quasinoides-pentaca%c2%adclicos-a-partir-de-acidos-comunicos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/aproximacion-a-la-sa%c2%adntesis-de-quasinoides-pentaca%c2%adclicos-a-partir-de-acidos-comunicos\/","title":{"rendered":"Aproximaci\u00f3n a la s\u00edntesis de quasinoides pentac\u00edclicos a partir de \u00e1cidos comunicos"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Romera Santiago Juan  Luis <\/strong><\/h2>\n<p>Quasinoides son un importante grupo de nor-terpenos naturales aislados de numerosas plantas de la familia de las simaroubaceae [1-2]. Seg\u00fan estudios realizados se originan biosint\u00e9ticamente en la degradaci\u00f3n oxidativa y reordenamiento de triterpenos tetrac\u00edclicos siendo por tanto nor-triterpenos.  de entre los diferentes tipos de quasinoides, suelen ser los de esqueleto pentac\u00edclico, los que muestran un mayor y m\u00e1s amplio rango de actividades biol\u00f3gicas. As\u00ed por ejemplo, bruceantina aislado de brucea antidysenterica, es un potente antileuc\u00e9mico, que ha sido evaluado en fase cl\u00ednica i [3-4] ailanthona, el compuesto mayoritario de los extractos de ailanthus altissima, tiene una interesante actividad antiulcerosa mostrando baja toxicidad [5], y brusatol tiene una potente actividad como antiinflamatorio, demostrando mayor actividad que indometacina [6].  durante varios a\u00f1os nuestro grupo de investigaci\u00f3n ha trabajado en la s\u00edntesis de quasinoides con potentes actividades biol\u00f3gicas, desarrollando una secuencia sint\u00e9tica, para la obtenci\u00f3n del esqueleto de picrasano, a partir de sintones homoquirales como los \u00e1cidos com\u00fanicos, aislados de diferentes especies de cupresaceas entre ellas juniperus communis [7-10].  el principal objetivo de esta tesis, es la optimizaci\u00f3n del proceso anterior, incluyendo el estudio de las fuentes del material de partida, \u00e1cidos com\u00fanicos, pasando por la optimizaci\u00f3n de la secuencia sint\u00e9tica hacia el esqueleto de nor-picrasano y concluyendo con el avance hacia la s\u00edntesis de quasinoides bioactivos.  una ventaja a la hora de llevar a cabo la s\u00edntesis, es poder disponer del anillo a convenientemente funcionalizado, ya que los \u00e1cidos com\u00fanicos no presentan ninguna funci\u00f3n directamente unida al anillo a. Siendo la \u00fanica v\u00eda de funcionalizaci\u00f3n, la degradaci\u00f3n a trav\u00e9s el \u00e1cido sobre c-4, planteamos el desarrollo de m\u00e9todos de degradaci\u00f3n que proporcionasen intermedios m\u00e1s adecuad<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Aproximaci\u00f3n a la s\u00edntesis de quasinoides pentac\u00edclicos a partir de \u00e1cidos comunicos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Aproximaci\u00f3n a la s\u00edntesis de quasinoides pentac\u00edclicos a partir de \u00e1cidos comunicos <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Romera Santiago Juan  Luis <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 27\/10\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Alejandro Fernandez Barrero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: isidro Gonzalez collado <\/li>\n<li> Herrador del pino m. del mar (vocal)<\/li>\n<li>Jos\u00e9 Mar\u00eda Miguel del corral santana (vocal)<\/li>\n<li>librada Mar\u00eda Ca\u00f1edo hern\u00e1ndez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Romera Santiago Juan Luis Quasinoides son un importante grupo de nor-terpenos naturales aislados de numerosas plantas de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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