{"id":26519,"date":"2018-03-09T09:18:22","date_gmt":"2018-03-09T09:18:22","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/el-control-de-la-secrecion-acida-en-el-raton-cambios-asociados-a-la-gastritis-y-a-la-falta-del-receptor-de-tipo-2-de-la-somatostatina\/"},"modified":"2018-03-09T09:18:22","modified_gmt":"2018-03-09T09:18:22","slug":"el-control-de-la-secrecion-acida-en-el-raton-cambios-asociados-a-la-gastritis-y-a-la-falta-del-receptor-de-tipo-2-de-la-somatostatina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/el-control-de-la-secrecion-acida-en-el-raton-cambios-asociados-a-la-gastritis-y-a-la-falta-del-receptor-de-tipo-2-de-la-somatostatina\/","title":{"rendered":"El control de la secreci\u00f3n \u00e1cida en el rat\u00f3n: cambios asociados a la gastritis y a la falta del receptor de tipo 2 de la somatostatina"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Laura Piqueras Ruiz <\/strong><\/h2>\n<p>Este estudio caracteriza los mecanismos de control de la secreci\u00f3n \u00e1cida g\u00e1strica (sag) in vivo en el rat\u00f3n en diferentes situaciones experimentales, tanto en condiciones normales como en estados son alteraciones potenciales en la funci\u00f3n g\u00e1strica y sus mecanismos de control, como en estados de gastritis o tras la manipulaci\u00f3n gen\u00e9tica dirigida a interferir factores implicados en la regulaci\u00f3n de la funci\u00f3n g\u00e1strica, en este caso el receptor de tipo 2 de la somatostatina (sstr2).  en el rat\u00f3n, la irritaci\u00f3n qu\u00edmica de la muscosa g\u00e1strica con yodoacetamida induce una gastritis leve, sin lesiones macro o microsc\u00f3picas, pero que resulta en una alteraci\u00f3n significativa de la sag. Estos cambios fundamentales se asocian a un balance entre:  1,- un incremento en la capacidad secretora g\u00e1strica, debido a una alteraci\u00f3n en los sistemas inhibitorios dependientes de somatostatina (sst) y\/o a un aumento en la eficacia de los sistemas estimulantes.  2,- un descenso en la capacidad secretora asociado a cambios, aumentos, en la s\u00edntesis de prostaglandinas. Adem\u00e1s, los resultados obtenidos demuestran que los mastocitos, c\u00e9lulas que no parecen tener un papel primario en la regulaci\u00f3n de la secreci\u00f3n \u00e1cida g\u00e1strica en condiciones normales, pero que son reclutados durante el proceso inflamatorio, pueden contribuir a las respuestas hipersecretoras g\u00e1stricas observadas.  por primera vez, se ha determinado de  forma sistem\u00e1tica la implicaci\u00f3n relativa de los diferentes subtipos de receptores de la somatostatina (sstr1-5) en el control de la secreci\u00f3n \u00e1cida. Adem\u00e1s, el empleo de un modelo animal anestesiado con uretano y la manipulaci\u00f3n tanto farmacol\u00f3gia como gen\u00e9tica de los receptores sstr2 confirman el papel esencial que desempe\u00f1an la sst y el receptor sstr2 en el control de la sag. Los resultados obtenidos sugieren que la sst act\u00faa a trav\u00e9s de receptores sstr2 inhibiendo la liberaci\u00f3n de histamina de c\u00e9lulas ecl y,<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>El control de la secreci\u00f3n \u00e1cida en el rat\u00f3n: cambios asociados a la gastritis y a la falta del receptor de tipo 2 de la somatostatina<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 El control de la secreci\u00f3n \u00e1cida en el rat\u00f3n: cambios asociados a la gastritis y a la falta del receptor de tipo 2 de la somatostatina <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Laura Piqueras Ruiz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 27\/10\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Vicente Martinez Perea<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: esteban Morcillo s\u00e1nchez <\/li>\n<li>esteban Saperas franch (vocal)<\/li>\n<li>isabel Guillen salazar (vocal)<\/li>\n<li>patrocinio Vergara esteras (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Laura Piqueras Ruiz Este estudio caracteriza los mecanismos de control de la secreci\u00f3n \u00e1cida g\u00e1strica (sag) in [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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