{"id":26538,"date":"2018-03-09T09:18:24","date_gmt":"2018-03-09T09:18:24","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-y-regulacion-farmacologica-in-vivo-de-la-neurotransmision-noradrenergica-y-su-modulacion-por-farmacos-serotonergicos-un-estudio-en-el-locus-coeruleus-de-rata\/"},"modified":"2018-03-09T09:18:24","modified_gmt":"2018-03-09T09:18:24","slug":"caracterizacion-y-regulacion-farmacologica-in-vivo-de-la-neurotransmision-noradrenergica-y-su-modulacion-por-farmacos-serotonergicos-un-estudio-en-el-locus-coeruleus-de-rata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/pais-vasco-euskal-herriko-unibertsitatea\/caracterizacion-y-regulacion-farmacologica-in-vivo-de-la-neurotransmision-noradrenergica-y-su-modulacion-por-farmacos-serotonergicos-un-estudio-en-el-locus-coeruleus-de-rata\/","title":{"rendered":"Caracterizaci\u00f3n y regulaci\u00f3n farmacol\u00f3gica in vivo de la neurotransmisi\u00f3n noradren\u00e9rgica y su modulaci\u00f3n por f\u00e1rmacos seroton\u00e9rgicos. un estudio en el locus coeruleus de rata."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Bego\u00f1a Fernandez Pastor <\/strong><\/h2>\n<p>En los \u00faltimos a\u00f1os se ha demostrado la existencia de noradrenalina en el \u00e1rea del locus coeruleus, aunque a\u00fan no se conocen bien sus procesos sin\u00e1pticos. La noradrenalina liberada en el \u00e1rea del locus coeruleus parece jugar un papel muy importante en la regulaci\u00f3n de la actividad de las neuronas noradren\u00e9rgicas de dicho n\u00facleo.  la inhibici\u00f3n de la recaptaci\u00f3n de noradrenalina y\/o serotonina es el mecanismo de acci\u00f3n de muchos f\u00e1rmacos antidepresivos. Aunque el proceso de recaptaci\u00f3n es r\u00e1pido, todav\u00eda hoy no se ha explicado el hecho de que dichos f\u00e1rmacos no ejerzan su efecto terap\u00e9utico hasta dos otres semanas tras el tratamiento.  los f\u00e1rmacos isrs son capaces de modular la actividad el\u00e9ctrica y neuroqu\u00edmica del sistema noradren\u00e9rgico, en parte, modulando la concentraci\u00f3n extracelular de noradrenalina en el locus coeruleus. Esta modulaci\u00f3n podr\u00eda tener importancia en su actividad cl\u00ednica como antidepresivos. Por todo ello, caracterizar los procesos sin\u00e1pticos de la noradrenaliona presente en el locus coeruleus, estudiar sus posibles funciones, as\u00ed como caracterizar los receptores de serotonina que a este nivel est\u00e1n implicados en la respuesta noradren\u00e9rgica, puede ser clave para entender la interacci\u00f3n entre ambos sistemas en los trastornos depresivos y su tratamiento farmacol\u00f3gico.  la t\u00e9cnica de microdi\u00e1lisi cerebral in vivo permite cuantificar concentraciones extracelulares de noradrenalina tanto en el locus coeruleus como en la corteza cingular. La noradrenalina presente en el locus coeruleus responde a patrones de s\u00edntesis, liberaci\u00f3n, almacenamiento, interacci\u00f3n con receptores y recaptaci\u00f3n similares los de la noradrenalina liberada en \u00e1reas terminales como la corteza cingular. La noradrenalina presente en el \u00e1rea del locus coeruleus ejerce un efecto t\u00f3nico inhibitorio sobre la liberaci\u00f3n de noradrenalina presente en el \u00e1rea del locus coeruleus ejerce un efecto t\u00f3nico inhibitorio sob<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n y regulaci\u00f3n farmacol\u00f3gica in vivo de la neurotransmisi\u00f3n noradren\u00e9rgica y su modulaci\u00f3n por f\u00e1rmacos seroton\u00e9rgicos. un estudio en el locus coeruleus de rata.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n y regulaci\u00f3n farmacol\u00f3gica in vivo de la neurotransmisi\u00f3n noradren\u00e9rgica y su modulaci\u00f3n por f\u00e1rmacos seroton\u00e9rgicos. un estudio en el locus coeruleus de rata. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Bego\u00f1a Fernandez Pastor <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 28\/10\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Javier Meana Martinez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: \u00e1ngel Pazos carro <\/li>\n<li>arsenio Fernandez lopez (vocal)<\/li>\n<li>susana Esteban vald\u00e9s (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Bego\u00f1a Fernandez Pastor En los \u00faltimos a\u00f1os se ha demostrado la existencia de noradrenalina en el \u00e1rea [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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