{"id":26539,"date":"2018-03-09T09:18:24","date_gmt":"2018-03-09T09:18:24","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/valoracion-de-la-maduracion-pulmonar-fetal-inducida-por-inhibidores-de-la-11-beta-hidroxiesteroide-deshidrogenasa-tipo-ii\/"},"modified":"2018-03-09T09:18:24","modified_gmt":"2018-03-09T09:18:24","slug":"valoracion-de-la-maduracion-pulmonar-fetal-inducida-por-inhibidores-de-la-11-beta-hidroxiesteroide-deshidrogenasa-tipo-ii","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/pais-vasco-euskal-herriko-unibertsitatea\/valoracion-de-la-maduracion-pulmonar-fetal-inducida-por-inhibidores-de-la-11-beta-hidroxiesteroide-deshidrogenasa-tipo-ii\/","title":{"rendered":"Valoraci\u00f3n de la maduraci\u00f3n pulmonar fetal inducida por inhibidores de la 11 beta hidroxiesteroide deshidrogenasa tipo ii"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Javier Guibert Valencia <\/strong><\/h2>\n<p>El cortisol materno es 5-10 superior al fetal gracias a que la placenta lo inactiva mediante la 11b hidroxiesteroide deshidrogenasa tipo ii. La inhibici\u00f3n de esta enzima con carbonexolona (cbx) permite que pase el cortisol materno al feto. Este aumento del cortisol fetal deber\u00eda inducir maduraci\u00f3n pulmonar como lo induce la administraci\u00f3n ex\u00f3gena de glucocorticoides fluorados en posici\u00f3n 9 (betametasona y dexametasona) que no son inhibidos por la enzima placentaria.  se ha realizado un estudio experimental randomizado y ciego para el observador con los siguientes objetivos: comprobar el efecto de cbx sobre la maduraci\u00f3n pulmonar, valorar la dosis efecto, compararlo con un madurador conocido (betametasona) e investigar posible sinergismo entre cbx y betametasona.  como sujetos de estudio se han utilizado ratas wistar divididas en 5 grupos de seg\u00fan sea la sustancia administrada los d\u00edas 16 y 17 de gestaci\u00f3n: suero salino fisiol\u00f3gico (ssf), cbx 12,5mg, cbx 75 mg, betametasona o betametasona m\u00e1s cbx.  el d\u00eda 19 se realiza ces\u00e1rea (t\u00e9rmino 21 d), y a los fetos se les valora la mudurez pulmonar mediante determinaciones cl\u00ednicas (peso fetal, peso pulmonar, patr\u00f3n respiratorio), determinaciones histol\u00f3gicas (microscop\u00eda \u00f3ptica y electr\u00f3nica) y par\u00e1metros bioqu\u00edmicos (recuento de cuerpos laminares en l\u00edquido amni\u00f3tico, cantidad de dna\/peso pulm\u00f3n, prote\u00ednas\/dna, fosfol\u00edpidos totales\/dna y fosfatid\u00edlcolina desaturada (dspc)).  la valoraci\u00f3n de las diferencias se ha realizado mediante x2, an\u00e1lisis de la varianza y t de student.  en el grupo cbx75 se ha encontrado un aumento de la producci\u00f3n de surfactante (dspc), aunque es menor que le producido por betametasona. En algunos par\u00e1metros (peso fetal y relaci\u00f3n peso pulmonar\/fetal) existe relaci\u00f3n dosis efecto. no se ha podido demostrar sinergismo entre cbx y betametasona.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Valoraci\u00f3n de la maduraci\u00f3n pulmonar fetal inducida por inhibidores de la 11 beta hidroxiesteroide deshidrogenasa tipo ii<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Valoraci\u00f3n de la maduraci\u00f3n pulmonar fetal inducida por inhibidores de la 11 beta hidroxiesteroide deshidrogenasa tipo ii <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Javier Guibert Valencia <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 28\/10\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Yon Albisu Andrade<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan Rodriguez soriano <\/li>\n<li>Jos\u00e9 Lopez sastre (vocal)<\/li>\n<li> Fraga berm\u00fadez Jos\u00e9 Mar\u00eda (vocal)<\/li>\n<li>martin Navarro merino (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Javier Guibert Valencia El cortisol materno es 5-10 superior al fetal gracias a que la placenta lo [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[12909],"tags":[34786,76721,59693,26318,1962,76722],"class_list":["post-26539","post","type-post","status-publish","format-standard","hentry","category-pais-vasco-euskal-herriko-unibertsitatea","tag-fraga-bermudez-jose-maria","tag-javier-guibert-valencia","tag-jose-lopez-sastre","tag-juan-rodriguez-soriano","tag-martin-navarro-merino","tag-yon-albisu-andrade"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/26539","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=26539"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/26539\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=26539"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=26539"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=26539"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}