{"id":26565,"date":"2018-03-09T09:18:27","date_gmt":"2018-03-09T09:18:27","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-del-promotor-del-factor-de-transcripcion-mitocondrial-tfam-regulacion-por-receptores-nucleares-y-factores-de-crecimiento\/"},"modified":"2018-03-09T09:18:27","modified_gmt":"2018-03-09T09:18:27","slug":"caracterizacion-del-promotor-del-factor-de-transcripcion-mitocondrial-tfam-regulacion-por-receptores-nucleares-y-factores-de-crecimiento","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-del-promotor-del-factor-de-transcripcion-mitocondrial-tfam-regulacion-por-receptores-nucleares-y-factores-de-crecimiento\/","title":{"rendered":"Caracterizaci\u00f3n del promotor del factor de transcripci\u00f3n mitocondrial tfam. regulaci\u00f3n por receptores nucleares y factores de crecimiento"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Kaninda Tshilumbu John Patrick <\/strong><\/h2>\n<p>Desde hace mucho tiempo se sabe que la hormona tiroidea (t3) juega un papel importante en la regulaic\u00f3n del metabolismo general, crecimiento y diferenciaci\u00f3n de diversos tipos celulares.  tambi\u00e9n, uno de los efectos m\u00e1s coocidos de t3 es su regulaci\u00f3n de la funcionalidad mitocondrial. Aunque este efecto sobre la mitocondria ha sido muy estudiado en tejidos como el h\u00edgado, se sabe mucho menos sobre su acci\u00f3n en las mitocondrias de cerebro, un \u00f3rgano que precisamente es muy dependiente del estado tiroideo durante el desarrollo. Datos previos del laboratorio han mostrado que la t3 es un importante regulador tanto de la expresi\u00f3n del genoma mitocondrial como de la funcionalidad de la mitocondrial tfam, una prote\u00edna muy importante en la biog\u00e9nesis de la mitocondria, podr\u00eda estar regulado por t3 en cerebro y por tanto actuar de mediador de la acci\u00f3n de esta hormona sobre las mitocondrias de este \u00f3rgano.  hemos demostrado que los niveles de mrna y prote\u00edna tfam est\u00e1n disminuidos en el cerebro de neonatos hipotiroideos y que estos niveles se recuperan despu\u00e9s de un tratamiento con t3, lo que indica que esta hormona es la causante de esta regulaci\u00f3n. Hemos demostrado tambi\u00e9n que la t3 induce la expresi\u00f3n del gen tfam en c\u00e9lulas de neuroblastoma, estando las secuencias responsables de esta activaci\u00f3n localizadas en un fragmento comprendido entre los nucl\u00e9otidos -145\/+1 y que tambi\u00e9n existe una secuencia localizada entre los nucle\u00f3tidos -1239\/-1212 que es capaz de mediar el efecto de esta hormona. El efecto de t3 sobre el promotor de tfam es espec\u00edfico de la isoforma trbeta1 del receptor de t3. Tambi\u00e9n, otros ligandos de receptroes nucleares como vitamina d3 (vd3) y \u00e1cido todo-trans retinoico (ar) son capaces de activar la expresi\u00f3n de tfam, mientras que 15 deoxy-* 12,14 -prostaglandina j2 (15d-pgj2), ligando del receptor nuclear ppargamma, inhibe significativamente la actividad de este promotor. Finalmente hemos observ<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n del promotor del factor de transcripci\u00f3n mitocondrial tfam. regulaci\u00f3n por receptores nucleares y factores de crecimiento<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n del promotor del factor de transcripci\u00f3n mitocondrial tfam. regulaci\u00f3n por receptores nucleares y factores de crecimiento <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Kaninda Tshilumbu John Patrick <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 30\/10\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ana Mar\u00eda P\u00e9rez Castillo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: gregorio angel Santos montes <\/li>\n<li>angel Pascual Garc\u00eda (vocal)<\/li>\n<li>Ana Mar\u00eda Aranda uriarte (vocal)<\/li>\n<li>\u00e1ngeles Mart\u00edn requero (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Kaninda Tshilumbu John Patrick Desde hace mucho tiempo se sabe que la hormona tiroidea (t3) juega un [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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