{"id":26570,"date":"2018-03-09T09:18:27","date_gmt":"2018-03-09T09:18:27","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/optimizacion-tecnologica-de-la-microencapsulacion-de-celulas-con-fines-terapeuticos\/"},"modified":"2018-03-09T09:18:27","modified_gmt":"2018-03-09T09:18:27","slug":"optimizacion-tecnologica-de-la-microencapsulacion-de-celulas-con-fines-terapeuticos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/pais-vasco-euskal-herriko-unibertsitatea\/optimizacion-tecnologica-de-la-microencapsulacion-de-celulas-con-fines-terapeuticos\/","title":{"rendered":"Optimizaci\u00f3n tecnol\u00f3gica de la microencapsulaci\u00f3n de c\u00e9lulas con fines terap\u00e9uticos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Gorka Orive Arroyo <\/strong><\/h2>\n<p>La microencapsulaci\u00f3n de c\u00e9lulas representa una nueva estrategia farmac\u00e9utica para la liberaci\u00f3n controlada de productos terap\u00e9uticos durante largos periodos de tiempo. La correcta selecci\u00f3n de l\u00edneas celulares as\u00ed como un \u00f3ptimo desarrollo tecnol\u00f3gico de los sistemas de inmovilizaci\u00f3n permite aplicar esta tecnolog\u00eda al tratamiento de m\u00faltiples patolog\u00edas cr\u00f3nicas.  en la presente memoria experimental se ha optimizado la tecnolog\u00eda de microencapsulaci\u00f3n de c\u00e9lulas, haciendo especial hincapi\u00e9 en la correcta elaboraci\u00f3n de lsa micropart\u00edculas as\u00ed como en la selecci\u00f3n de los materiales en funci\u00f3n de sus propiedades de biocompatibilidad. Inicialmente, se han optimizado microc\u00e1psulas de alginato-agarosa recubiertas con poli-l-lisina y una membrana adicional de alginato con el fin de mejorar la biocompatibilidad del sistema. Tras encapsular hibridomas 1b5 secretores de un anticuerpo monoclonal anticaderina-vw, se observ\u00f3 que las c\u00e9lulas permanec\u00eda viables y secretaban anticuerpo a lo largo del estudio, logr\u00e1ndose una concentraci\u00f3n acumulada de 1,7 ug\/ml en el medio de cultivo. Paralelamente, se inmovilizaron fibroblastos y mioblastos observ\u00e1ndose un crecimiento controlado en el interior de la matriz, una elevada viabilidad y un alto grado de bioseguridad. Otro hito de esta memoria experimental fue la de evaluar la biocompatibilidad de diferentes tipos de alginatos. Los resultados demostraron que alginato purificado rico en \u00e1cidos gulur\u00f3nicos, a diferencia de los alginatos no purificados ricos tanto en \u00e1cidos gulur\u00f3nicos como en \u00e1cidos manur\u00f3nicos, presentaban un menor contenido en prote\u00ednas, polifenoles y endotoxinas y no desencadenaba una respuesta antig\u00e9nica tras su administraci\u00f3n a ratones.  finalmente, se han elaborado y optimizado microc\u00e1psulas de alginato recubiertas con el policati\u00f3n poli(metilen-co-guanidina) (pmcg) con el fin de encontrar una alternativa al uso de policati\u00f3n poli-l-lisina<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Optimizaci\u00f3n tecnol\u00f3gica de la microencapsulaci\u00f3n de c\u00e9lulas con fines terap\u00e9uticos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Optimizaci\u00f3n tecnol\u00f3gica de la microencapsulaci\u00f3n de c\u00e9lulas con fines terap\u00e9uticos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Gorka Orive Arroyo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 30\/10\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Luis Pedraz Mu\u00f1oz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: alfonso Jes\u00fas Dominguez gil hurle <\/li>\n<li>felix Mar\u00eda Go\u00f1i urcelay (vocal)<\/li>\n<li>amparo S\u00e1nchez navarro (vocal)<\/li>\n<li>jordi Alberch i vie (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gorka Orive Arroyo La microencapsulaci\u00f3n de c\u00e9lulas representa una nueva estrategia farmac\u00e9utica para la liberaci\u00f3n controlada de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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