{"id":26600,"date":"2018-03-09T09:18:30","date_gmt":"2018-03-09T09:18:30","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estructura-y-plegamiento-de-lytc-y-cpl-1-dos-lisozimas-que-hidrolizan-la-pared-celular-de-streptococcus-pneumoniae\/"},"modified":"2018-03-09T09:18:30","modified_gmt":"2018-03-09T09:18:30","slug":"estructura-y-plegamiento-de-lytc-y-cpl-1-dos-lisozimas-que-hidrolizan-la-pared-celular-de-streptococcus-pneumoniae","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estructura-y-plegamiento-de-lytc-y-cpl-1-dos-lisozimas-que-hidrolizan-la-pared-celular-de-streptococcus-pneumoniae\/","title":{"rendered":"Estructura y plegamiento de lytc y cpl-1, dos lisozimas que hidrolizan la pared celular de streptococcus pneumoniae"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Bego\u00f1a Monterroso Marco <\/strong><\/h2>\n<p>Las enzimas l\u00edticas de streptococcus pneumoniae constituyen un claro ejemplo de organizaci\u00f3n modular.  todas ellas presentan un m\u00f3dulo catal\u00edtico y un m\u00f3dulo de uni\u00f3n al sustrato por el reconocimiento espec\u00edfico de los residuos de colina presentes en la pared de neumococo. Cada una de las enzimas l\u00edticas codificadas por la bacteria ejerce su actividad sobre distintos puntos de la pared, participando en la correcta formaci\u00f3n de pared celular en el crecimiento, en la separaci\u00f3n delas c\u00e9lulas hijas tras la divisi\u00f3n y en la lisis en la fase estacionaria. as\u00ed, la amidasa lyta, que es la autolisina mayoritaria en nuemococo, reompe los enlaces amida que se establecen entre los residuos de \u00e1cido n-acetilmur\u00e1nico (nam) y las cortas cadenas pept\u00eddicas que contribuyen a la estabilizaci\u00f3n de la pared al unirse entre s\u00ed. La lisoxima, lytc, corta los enlaces glicos\u00eddicos que unen los az\u00facares nam y glucosmaina, cuya alternancia da lugar a las cadenas glic\u00e1nicas que forman la pared. Por \u00faltimo, lytb presenta actividad glucosaminidasa, hidrolizando los enlaces glicos\u00eddicos entre la glucosamina y el nam. Las endolisinas codificadas por los fagos que infectan esta baceter\u00eda presentan esta misma disposici\u00f3n modular. De hecho, la gran similitud existen entre los m\u00f3dulos con la misma funci\u00f3n de las enzimas bacterianas y f\u00e1gicas apunta hacia un intercambio g\u00e9nico entre ambos microorganismos. Sin embargo, existen entre ellas diferencias estructurales que probablemente se traducen en su distinta regulaci\u00f3n biol\u00f3gica, puesto que \u00e9stas est\u00e1n reguladas por el ciclo f\u00e1gico del virus.  la caracterizaci\u00f3n estructural a baja y alta resoluci\u00f3n de lytc y cpl-1, lisoximas codificadas por neumococo y el fago cp-1, respectivamente, ha permitido establecer ciertas diferencias estructurales entre ellas y con relaci\u00f3n a la otras estructura de un miembro de la familia de prote\u00ednas que unen colina conocida hasta el momento, c-lyta. As\u00ed, la<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estructura y plegamiento de lytc y cpl-1, dos lisozimas que hidrolizan la pared celular de streptococcus pneumoniae<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estructura y plegamiento de lytc y cpl-1, dos lisozimas que hidrolizan la pared celular de streptococcus pneumoniae <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Bego\u00f1a Monterroso Marco <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 31\/10\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Margarita Menendez Fernandez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Garc\u00eda blanco <\/li>\n<li>pedro Garc\u00eda gonz\u00e1lez (vocal)<\/li>\n<li>Juan Hermoso dominguez (vocal)<\/li>\n<li>arturo Muga villate (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Bego\u00f1a Monterroso Marco Las enzimas l\u00edticas de streptococcus pneumoniae constituyen un claro ejemplo de organizaci\u00f3n modular. todas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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