{"id":26614,"date":"2018-03-09T09:18:31","date_gmt":"2018-03-09T09:18:31","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/expresion-tisular-de-los-componentes-del-sistema-fibrinola%c2%adtico-y-de-las-metaloproteasas-en-la-endometriosis\/"},"modified":"2018-03-09T09:18:31","modified_gmt":"2018-03-09T09:18:31","slug":"expresion-tisular-de-los-componentes-del-sistema-fibrinola%c2%adtico-y-de-las-metaloproteasas-en-la-endometriosis","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/expresion-tisular-de-los-componentes-del-sistema-fibrinola%c2%adtico-y-de-las-metaloproteasas-en-la-endometriosis\/","title":{"rendered":"Expresi\u00f3n tisular de los componentes del sistema fibrinol\u00edtico y de las metaloproteasas en la endometriosis"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Juan Gilabert Estelles <\/strong><\/h2>\n<p>El objetivo del presente proyecto de tesis doctoral es analizar diversos componentes del sistema fibrinol\u00edtico y de las metaloproteasas en muestras de tejido proveniente de 55 pacientes con endometriosis y 37 mujeres consideradas como control. Se ha realizado un an\u00e1lisis cuantitativo mediante elisa de los niveles antig\u00e9nicos de los activadores fibrinol\u00edticos (tpa, upa, upar) y sus inhibidores (pai-1, pai-2, pai-3), as\u00ed como la mmp-3 y el timp-1, en el endometrio y  el l\u00edquido peritoneal de ambos grupos y en el tejido proveniente del endometrioma ov\u00e1rico de las pacientes con endometriosis. adem\u00e1s se determin\u00f3 por una t\u00e9cnica de sustarto cromog\u00e9nico los niveles funcionales de tpa, upa y pat-1.  se ha observado un aumento del nivel antig\u00e9nico de upa y mmp-3 en el endometrio de mujeres con endometriosis y un aumento de pai-1 y timp-1 en el endometrioma ov\u00e1rica de estas pacientes. El pai-3 se encontraba disminuido en el endometrioma ov\u00e1rico. El estudio de l\u00edquido peritoneal demostr\u00f3 un aumento de upa antig\u00e9nica en el mismo en los estadios avanzados de la enfermedad. No se encontraron diferencias en funci\u00f3n de la evoluci\u00f3n de la enfermedad, en t\u00e9rminos de recidiva, en ninguno de los par\u00e1metros.  adem\u00e1s, se procedi\u00f3 a la localizaci\u00f3n tisular de la expresi\u00f3n proteica de upa, pai-1 y pai-3 mediante inmunohistoqu\u00edmica. La se\u00f1al de upa es mayor en el endometrio de la mujer con endometriosis y se localiza tanto a nivel glandular como en el estroma. El pai-1 se expresa con intensidad en el endometrioma ov\u00e1rico, a nivel del epitelio, el estroma y el endotelio vascular. la se\u00f1al de pai-3 en el endomterioma es de moderada intensidad y  de localizaci\u00f3n estromal. Por otra parte, se estudi\u00f3 la expresi\u00f3n mediante hibridaci\u00f3n in situ de pai-1, siendo la misma d\u00e9bil en el endometrio de la mujer con endometriosis y los controles e intensa en el endometrioma, fundamentalmente a nivel epitelial, estromal y endotelial.  nuestros<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Expresi\u00f3n tisular de los componentes del sistema fibrinol\u00edtico y de las metaloproteasas en la endometriosis<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Expresi\u00f3n tisular de los componentes del sistema fibrinol\u00edtico y de las metaloproteasas en la endometriosis <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Juan Gilabert Estelles <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 31\/10\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan Gilabert Aguilar<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  jos\u00e9 Parrilla paricio <\/li>\n<li>Garc\u00eda Vicente (vocal)<\/li>\n<li>enrique Alborch dominguez (vocal)<\/li>\n<li>josep Mar\u00eda Lailla vicens (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Juan Gilabert Estelles El objetivo del presente proyecto de tesis doctoral es analizar diversos componentes del sistema [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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