{"id":26620,"date":"2018-03-09T09:18:31","date_gmt":"2018-03-09T09:18:31","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/la-quimioquina-sdf-1-regulacion-de-su-expresion-y-papel-en-la-modulacion-de-la-adhesion-celular-dependiente-de-integrinas-alfa4\/"},"modified":"2018-03-09T09:18:31","modified_gmt":"2018-03-09T09:18:31","slug":"la-quimioquina-sdf-1-regulacion-de-su-expresion-y-papel-en-la-modulacion-de-la-adhesion-celular-dependiente-de-integrinas-alfa4","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/la-quimioquina-sdf-1-regulacion-de-su-expresion-y-papel-en-la-modulacion-de-la-adhesion-celular-dependiente-de-integrinas-alfa4\/","title":{"rendered":"La quimioquina sdf-1: regulaci\u00f3n de su expresi\u00f3n y papel en la modulaci\u00f3n de la adhesi\u00f3n celular dependiente de integrinas alfa4"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Natalia Wright <\/strong><\/h2>\n<p>La quimioquina sdf-1 se expresa en c\u00e9lulas estromales de m\u00e9dula \u00f3sea y juega un papel fundamental en la migraci\u00f3n de c\u00e9lulas presentes en la m\u00e9dula \u00f3sea. La modulaci\u00f3n de su expresi\u00f3n podr\u00eda afectar a la capacidad migratoria de las c\u00e9lulas presentes en la m\u00e9dula \u00f3sea, como progenitores hematopoy\u00e9ticos o c\u00e9lulas leuc\u00e9micas. La citoquina tgf-beta1 est\u00e1 presente en el ambiente de la m\u00e9dula \u00f3sea, y constituye una mol\u00e9cula clave en el control de la proliferaci\u00f3n y diferenciaci\u00f3n celular en la m\u00e9dula \u00f3sea. Hemos empleado la l\u00ednea celular de estroma medular ms-5 como modelo, para estudiar si la expresi\u00f3n de sdf-1 constituye una diana para la regulaci\u00f3n por tgf-beta1, y sus consecuencias funcionales. Mostramos que tgf-beta1 reduce la expresi\u00f3n de sdf-1, tanto a nivel de mrna, implicando un descenso en la eficiencia de transcripci\u00f3n, como a nivel de prote\u00edna, detectado en sobrenadantes y lisados de c\u00e9lulas ms-5. El descenso de sdf-1 en los sobrenadantes de c\u00e9lulas ms-5 tratadas con tgf-beta1, se correlaciona con un descenso de la respuesta quimiot\u00e1ctica y de migraci\u00f3n transendotelial, dependiente de sdf-1, de las l\u00edneas celulares nci-h929 y mo7e, as\u00ed como de c\u00e9lulas cd34+ purificadas a partir de sangre de cord\u00f3n ubilical. Adicionalmente, los sobrenadantes de c\u00e9lulas ms-5 tratadas con tgf-beta1 pose\u00edan notablemente reducida su capacidad de desencadenar un aumento de adhesi\u00f3n dependiente de las integrinas alfa4beta1 y alfa5beta1. Estos datos indican que la reducci\u00f3n de la expresi\u00f3n de sdf-1 por tgf-beta1 es capaz de afectar la migraci\u00f3n y adhesi\u00f3n celular en la m\u00e9dula \u00f3sea.  por otra parte, la interacci\u00f3n de la integrina alfa4beta7 con su ligando madcam-1 constituye, presente en las v\u00e9nulas del endotelio alto del tracto gastrointestinal, representa un evento clave en la extravasaci\u00f3n linfocitaria a \u00f3rganos linfoides secundarios. En este trabajo demostramos que sdf-1alfa induce un aumento de ahesi\u00f3n<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>La quimioquina sdf-1: regulaci\u00f3n de su expresi\u00f3n y papel en la modulaci\u00f3n de la adhesi\u00f3n celular dependiente de integrinas alfa4<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 La quimioquina sdf-1: regulaci\u00f3n de su expresi\u00f3n y papel en la modulaci\u00f3n de la adhesi\u00f3n celular dependiente de integrinas alfa4 <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Natalia Wright <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 31\/10\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Joaquin Teixid\u00f3 Calvo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Miguel angel (secretario) Alonso lebrero <\/li>\n<li>Francisco Sanchez Madrid (vocal)<\/li>\n<li>angeles Garcia pardo (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Natalia Wright La quimioquina sdf-1 se expresa en c\u00e9lulas estromales de m\u00e9dula \u00f3sea y juega un papel [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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