{"id":26655,"date":"2003-04-11T00:00:00","date_gmt":"2003-04-11T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/17-b-estradiol-y-metabolitos-en-la-cardiopata%c2%ada-y-estres-oxidativo-inducido-por-adriamicina-en-ratas-ovariectomizadas\/"},"modified":"2003-04-11T00:00:00","modified_gmt":"2003-04-11T00:00:00","slug":"17-b-estradiol-y-metabolitos-en-la-cardiopata%c2%ada-y-estres-oxidativo-inducido-por-adriamicina-en-ratas-ovariectomizadas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/cordoba\/17-b-estradiol-y-metabolitos-en-la-cardiopata%c2%ada-y-estres-oxidativo-inducido-por-adriamicina-en-ratas-ovariectomizadas\/","title":{"rendered":"17 b estradiol y metabolitos en la cardiopat\u00eday estr\u00e9s oxidativo inducido por adriamicina en ratas ovariectomizadas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Juan  Rafael Mu\u00f1oz Casta\u00f1eda <\/strong><\/h2>\n<p>Estudios recientes muestran una relaci\u00f3n entre los niveles hormonas sexuales femeninas, el estado oxidativo y los trastornos cardiovasculares. Estos datos ponen en evidencia que los estr\u00f3genos protegen contra el estr\u00e9s oxidativo, disminuyendo la oxidaci\u00f3n de ldl, asimismo, estas hormonas modulan la reactividad arterial mediante la s\u00edntesis de \u00f3xido n\u00edtrico y prostaglandinas.  el presente trabajo tiene como objetivo principal valorar los efectos del 17 b-estradiol y sus metabolitos sobre la cardiotoxicidad y estr\u00e9s oxidativo inducido por adriamicina en rata wistar ovariectomizadas. 17 b-estradiol (2.5 mg\/kg peso\/s.C.), As\u00ed como 2-hidroxiestradiol y 4-hidroxiestradio (0.9 mg\/kg peso\/s.C.) Fueron administrados en d\u00edas alternos durante 18 d\u00edas, adrimicina (ad) (10 mg\/kg peso\/i.P.) Se inyect\u00f3 en dos dosis separadas entre s\u00ed por 9 d\u00edas, mientras que, la ovariectom\u00eda bilateral (ovx) se realiz\u00f3 seg\u00fan t\u00e9cnica descrita por pomeau-delille. Durante el periodo de estudio se procedi\u00f3 a la pesada, toma de presi\u00f3n arterial y frecuencia card\u00edaca de los animales. Tras el sacrificio se tomaron de muestras snagu\u00edneas del tronco vascular del cuello para: valoraci\u00f3n de da\u00f1o card\u00edaco (ast, alt, ldh yck), estr\u00e9s oxidativo (mda y gsh), actividad enzim\u00e1tica (sod y gpx). as\u00ed mismo, se procedi\u00f3 a la extracci\u00f3n y homogenizaci\u00f3n del tejido card\u00edaco al objeto de valorar el estado oxidativo (mda,prote\u00ednas carboniladas, \u00f3xido n\u00edtrico y gsh) y actividad enzim\u00e1tica (sod, catalasa, p450, gpx, grd y gtr). Tanto ovx como ad inducen cambios hemodin\u00e1micos, cit\u00f3lisis card\u00edaca y estr\u00e9s oxidativo tanto card\u00edaco como sangu\u00edneo. Estos fen\u00f3menos se potencian cuando ambas situaciones experimentales acontecen de manera simult\u00e1nea en el animal y ponen de manifiesto la participaci\u00f3n de las especies reactivas del ox\u00edgeno en la patog\u00e9nesis de la lesi\u00f3n card\u00edaca. As\u00ed mismo, tanto 17b-estradiol como sus derivados hidroxilados, 2-hidroxiestradio<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>17 b estradiol y metabolitos en la cardiopat\u00eday estr\u00e9s oxidativo inducido por adriamicina en ratas ovariectomizadas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 17 b estradiol y metabolitos en la cardiopat\u00eday estr\u00e9s oxidativo inducido por adriamicina en ratas ovariectomizadas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Juan  Rafael Mu\u00f1oz Casta\u00f1eda <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 04\/11\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Pedro Montilla Lopez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: emilio Fernandez reyes <\/li>\n<li>Juan  Andr\u00e9s Garc\u00eda rom\u00e1n (vocal)<\/li>\n<li>Jos\u00e9 Vi\u00f1a ribes (vocal)<\/li>\n<li> Ru\u00edz larrea Mar\u00eda bego\u00f1a (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Juan Rafael Mu\u00f1oz Casta\u00f1eda Estudios recientes muestran una relaci\u00f3n entre los niveles hormonas sexuales femeninas, el estado [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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