{"id":26663,"date":"2003-05-11T00:00:00","date_gmt":"2003-05-11T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/ribozimas-hairpin-y-hammerhead-como-base-para-el-diseno-de-rnas-inhibidores\/"},"modified":"2003-05-11T00:00:00","modified_gmt":"2003-05-11T00:00:00","slug":"ribozimas-hairpin-y-hammerhead-como-base-para-el-diseno-de-rnas-inhibidores","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/ribozimas-hairpin-y-hammerhead-como-base-para-el-diseno-de-rnas-inhibidores\/","title":{"rendered":"Ribozimas hairpin y hammerhead como base para el dise\u00f1o de rnas inhibidores"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Elena Puerta Fern\u00e1ndez <\/strong><\/h2>\n<p>A principio de la d\u00e9cada de los ochenta se describi\u00f3 por primera vez la capacidad de ciertas mol\u00e9culas de rna para catalizar reacciones qu\u00edmicas. a estas mol\u00e9culas de rna se las denomin\u00f3 ribozimas, y desde entoces han sido sometidas a un exahustiva estudio para determinar sus caracter\u00edsticas. la mayor\u00eda de las ribozimas naturales catalizan las reacciones de corte y\/o ligaci\u00f3n de otras mol\u00e9culas de rna (sustrato), de un modo altamente espec\u00edfico de secuencia. Estas caracter\u00edsticas ha hecho que se desarrolle una tecnolog\u00eda de ribozimas encaminada hacia la generaci\u00f3n de nuevas herramientas terap\u00e9uticas.  la cat\u00e1lisis qu\u00edmica mediada por ribozimas requiere el contar con motivos catal\u00edticos capaces de interaccionar de un modo efectivo conla mol\u00e9ucla diana. El objetivo principal de esta tesis doctoral consisti\u00f3 en la generaci\u00f3n de nuevas mol\u00e9culas inhibidoras, basadas en ribozimas, con las caracter\u00edsticas de interacci\u00f3n al sustrato optimizadas. Estas nuevas mol\u00e9culas inhibidoras se denominaron rnas antisense catal\u00edticos.  en la naturaleza existen sistemas en los cuales la regulaci\u00f3n de diversos procesos est\u00e1 mediada por la interacci\u00f3n eficiente entre mol\u00e9culas de rna; son los sistemas de los rnas antisense naturales, y un exhaustivo conocimiento de los mismos permite afirmar que la velocidad de asociaci\u00f3n entre estas mol\u00e9culas de rna, y la especificidad del sistema vienen determinada por la presencia de elementos estructurales tallo-lazo en estas mol\u00e9culas.  el conocimiento obtenido del estudio de estos sistemas naturales nos proporcion\u00f3 la informaci\u00f3n necesaria para la generaci\u00f3n de los rnas antisense catal\u00edticos. se trata de mol\u00e9culas de rna compuestas por un motivo catal\u00edtico, robozimas hairpin \u00f3 hammerhead, y de un motivo antisense, estructura tallo-lazo complementaria a una presente en el rna sustrato.  las mol\u00e9culas generadas se ensayaron frente a sustratos artificiales  de distinta longitud, co<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Ribozimas hairpin y hammerhead como base para el dise\u00f1o de rnas inhibidores<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Ribozimas hairpin y hammerhead como base para el dise\u00f1o de rnas inhibidores <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Elena Puerta Fern\u00e1ndez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 05\/11\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Alfredo Berzal Herranz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ricardo Flores pedauye <\/li>\n<li>Mar\u00eda  purificacion Fortes alonso (vocal)<\/li>\n<li>Carlos Ciudad g\u00f3mez (vocal)<\/li>\n<li>Francisco Mart\u00ednez-abarca pastor (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Elena Puerta Fern\u00e1ndez A principio de la d\u00e9cada de los ochenta se describi\u00f3 por primera vez la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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