{"id":26716,"date":"2003-07-11T00:00:00","date_gmt":"2003-07-11T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/formacion-de-enlaces-carbono-carbono-mediante-catalisis-de-sales-metalicas-y-de-dendra%c2%admeros-aplicacion-a-la-sa%c2%adntesis-de-inhibidores-de-interacciones-protea%c2%adna-protea%c2%adna\/"},"modified":"2003-07-11T00:00:00","modified_gmt":"2003-07-11T00:00:00","slug":"formacion-de-enlaces-carbono-carbono-mediante-catalisis-de-sales-metalicas-y-de-dendra%c2%admeros-aplicacion-a-la-sa%c2%adntesis-de-inhibidores-de-interacciones-protea%c2%adna-protea%c2%adna","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/pais-vasco-euskal-herriko-unibertsitatea\/formacion-de-enlaces-carbono-carbono-mediante-catalisis-de-sales-metalicas-y-de-dendra%c2%admeros-aplicacion-a-la-sa%c2%adntesis-de-inhibidores-de-interacciones-protea%c2%adna-protea%c2%adna\/","title":{"rendered":"Formaci\u00f3n de enlaces carbono-carbono mediante cat\u00e1lisis de sales met\u00e1licas y de dendr\u00edmeros. aplicaci\u00f3n a la s\u00edntesis de inhibidores de interacciones prote\u00edna-prote\u00edna"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Aizpea Zubia Olascoaga <\/strong><\/h2>\n<p>La presente tesis consta de dos partes. En la primera se realiza un estudio experimental y computacional de la relaci\u00f3n entre la estructura y la actividad catal\u00edtica de dendr\u00edmeros con un \u00fanico centro activo situado en el core y con distintos grados de generaci\u00f3n y ramificaci\u00f3n. Se describe la s\u00edntesis y caracterizaci\u00f3n de poli (aril\u00e9teres) con una amina terciaria en el core, y el procedimiento cin\u00e9tico para determinar su actividad catal\u00edtica en la reacci\u00f3n entre el 2-nitroetanol y el benzaldeh\u00eddo. Adem\u00e1s se realizan simulaciones de din\u00e1mica molecular de estos catalizadores dendrim\u00e9ricos para calcular sus par\u00e1metros estructurales. Se ha encontrado una correlaci\u00f3n lineal entre los citados par\u00e1metros estructurales y el coeficiente de velocidad medido para la reacci\u00f3n antes mencionada. Este comportamiento se aleja de forma lineal del descrito por la teor\u00eda de colisi\u00f3n de esferas r\u00edgidas.  en la segunda parte se estudia la aplicabilidad de nitroaldoles adecuadamente funcionalizados en la s\u00edntesis de inhibidores de interacciones prote\u00edna-prote\u00edna. se describe la s\u00edntesis regio- y estereocontrolada de dip\u00e9ptidos derivados de nitropolinas no naturales, obtenidas mediante cicloadici\u00f3n [3+2] entre iluros de azometino emtalados y nitroalquenos homoquirales, con posible actividad inhibitoria de interacciones integrima-lingando vla-4\/vcam-1 y lfa-1\/icam-1.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Formaci\u00f3n de enlaces carbono-carbono mediante cat\u00e1lisis de sales met\u00e1licas y de dendr\u00edmeros. aplicaci\u00f3n a la s\u00edntesis de inhibidores de interacciones prote\u00edna-prote\u00edna<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Formaci\u00f3n de enlaces carbono-carbono mediante cat\u00e1lisis de sales met\u00e1licas y de dendr\u00edmeros. aplicaci\u00f3n a la s\u00edntesis de inhibidores de interacciones prote\u00edna-prote\u00edna <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Aizpea Zubia Olascoaga <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 07\/11\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Coss\u00edo Mora Fernando Pedro<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: soledad Penad\u00e9s ullate <\/li>\n<li>Fernando Vidal vanaclocha (vocal)<\/li>\n<li>enrique D\u00edez barra (vocal)<\/li>\n<li> De la torre egido M\u00aa carmen (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Aizpea Zubia Olascoaga La presente tesis consta de dos partes. En la primera se realiza un estudio [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[12909],"tags":[77143,57281,77144,5451,12983,31739],"class_list":["post-26716","post","type-post","status-publish","format-standard","hentry","category-pais-vasco-euskal-herriko-unibertsitatea","tag-aizpea-zubia-olascoaga","tag-cossio-mora-fernando-pedro","tag-de-la-torre-egido-ma-carmen","tag-enrique-diez-barra","tag-fernando-vidal-vanaclocha","tag-soledad-penades-ullate"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/26716","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=26716"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/26716\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=26716"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=26716"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=26716"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}