{"id":26723,"date":"2003-07-11T00:00:00","date_gmt":"2003-07-11T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sobre-el-papel-patogenico-del-peptido-beta-amiloide-en-la-enfermedad-de-alzheimer\/"},"modified":"2003-07-11T00:00:00","modified_gmt":"2003-07-11T00:00:00","slug":"sobre-el-papel-patogenico-del-peptido-beta-amiloide-en-la-enfermedad-de-alzheimer","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sobre-el-papel-patogenico-del-peptido-beta-amiloide-en-la-enfermedad-de-alzheimer\/","title":{"rendered":"Sobre el papel patog\u00e9nico del p\u00e9ptido beta-amiloide en la enfermedad de alzheimer"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Elena Serrano Carballal <\/strong><\/h2>\n<p>La enfermedad de alzheimer es un s\u00edndrome neurodegenerativo multifactorial y multig\u00e9nico, en el que se ha implicado al p\u00e9ptido abeta como agente causal. en este estudio, hemos analizado, en un modelo celular de neuroblastoma humano, la toxicidad del p\u00e9ptido amiloidog\u00e9nico abeta25-35 y el efecto de apoe sobre dicha toxicidad, y en segundo lugar, las consecuencias de las obreexpresi\u00f3n de app en este neuroblastoma.  el p\u00e9ptido abeta25-35 produjo una p\u00e9rdida de viabilidad, acompa\u00f1ada de la formaci\u00f3n de especies reactivas de ox\u00edgeno (ros) en la l\u00ednea de neuroblastoma humano sk-n-mc. As\u00ed mismo, a concentraciones subt\u00f3xicas, activaba al factor de transcripci\u00f3n nf-kb. La prote\u00edna apoe, independientemente de isoforma, restauraba la viabilidad del neuroblatoma tratado con abeta25-35, si bien, por s\u00ed misma, no ten\u00eda efecto sobre la viabilidad del cultivo.  por otra parte, hemos generado, mediante la transfecci\u00f3n del cdna completo correspondiente a la isoforma 695 de la prote\u00edna app, dos l\u00edneas de neuroblastoma humano -c2 y c3- que sobreexpresan de forma estable dicha prote\u00edna. Ambasl\u00edneas secretan abeta1-40 al medio, y la l\u00ednea con mayor expresi\u00f3n de app (c2), secreta tambi\u00e9n abeta1-42. As\u00ed mismo, ambas l\u00edneas presentan unos niveles de muerte celular basal que no presenta la l\u00ednea sk-n-mc ni una l\u00ednea celular control (c1-) generada por transfecci\u00f3n de este neuroblastoma con el mismo vector de expresi\u00f3n utilizado para generar las l\u00edneas c2 y c3, pero sin el inserto que codifica la prote\u00edna app695. Dicha muerte presenta caracter\u00edsticas propias del programa apopt\u00f3tico de muerte celular. Los experimentos de cocultivo celular, inducci\u00f3n de la muerte por privaci\u00f3n de suero y la inhibici\u00f3n de la muerte apopt\u00f3tica con un inhibidor de caspasas (z-vad-fmk) mostraron que el p\u00e9ptido abeta producido por las l\u00edneas celulares no era el responsable de la muerte celular. La prote\u00edna apoe no ten\u00eda ning\u00fan efecto, positivo o<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Sobre el papel patog\u00e9nico del p\u00e9ptido beta-amiloide en la enfermedad de alzheimer<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Sobre el papel patog\u00e9nico del p\u00e9ptido beta-amiloide en la enfermedad de alzheimer <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Elena Serrano Carballal <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 07\/11\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda Recuero Vicente<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: federico Mayor zaragoza <\/li>\n<li>Antonio Garc\u00eda Garc\u00eda (vocal)<\/li>\n<li>Alberto Portera s\u00e1nchez (vocal)<\/li>\n<li>Jos\u00e9 Mar\u00eda Medina jimenez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Elena Serrano Carballal La enfermedad de alzheimer es un s\u00edndrome neurodegenerativo multifactorial y multig\u00e9nico, en el que [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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