{"id":26733,"date":"2003-07-11T00:00:00","date_gmt":"2003-07-11T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estrategias-de-inhibicion-de-citocinas-proinflamatorias-en-un-modelo-de-sepsis-impacto-sobre-las-alteraciones-hemostaticas-y-la-generacion-de-quimocinas\/"},"modified":"2003-07-11T00:00:00","modified_gmt":"2003-07-11T00:00:00","slug":"estrategias-de-inhibicion-de-citocinas-proinflamatorias-en-un-modelo-de-sepsis-impacto-sobre-las-alteraciones-hemostaticas-y-la-generacion-de-quimocinas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/navarra\/estrategias-de-inhibicion-de-citocinas-proinflamatorias-en-un-modelo-de-sepsis-impacto-sobre-las-alteraciones-hemostaticas-y-la-generacion-de-quimocinas\/","title":{"rendered":"Estrategias de inhibici\u00f3n de citocinas proinflamatorias en un modelo de sepsis. impacto sobre las alteraciones hemost\u00e1ticas y la generaci\u00f3n de quimocinas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Pablo Rodr\u00edguez Wilhelmi <\/strong><\/h2>\n<p>Introducci\u00f3n  se cree que el tnf-alfa y la il-1beta son mediadores de la endotoxina (lps) capaces de estimular el endotelio vascular y los leucocitos circulantes a trav\u00e9s de diversas acciones que conllevan a un estado proinflamatorio y protromb\u00f3tico. Sin embargo, no existe unanimidad en cuanto al papel que tienen estas mol\u00e9culas en la sepsis severa.  hip\u00f3tesis y objetivos  el tnf-alfa y la il-1beta juegan un papel crucial en el disbalance hemost\u00e1tico y la generaci\u00f3n de quimocinas inducidos por lps. Nuestro objetivo fue intentar demostrar si el tnf-alfa y la il-1beta son las responsables de estos efectos en un modelo de sepsis severa en conejos.  m\u00e9todos  la sepsis se indujo mediante lps a dosi sde 100 ug\/kg\/h\/6h a conejos macho de raza nueva zelanda. En un primer estudio, los animales recibieron s\u00f3lo lps  (n=11) o lps m\u00e1s fr167653, un inhibidor simult\u00e1neo de la producic\u00f3n de tnf-alfa\/il-1beta, a tres dosis: 0,25 (n=9), 0,5 (n=9) y 1 (n=8) mg\/kg\/h\/6h. en un segundo estudio, se administr\u00f3 s\u00f3lo lps (n=11) o lps m\u00e1s un anticuerpo monoclonal (ac mo) anti-tnf-alfa (n=10), un bolus inicial de 20 mg\/kg seguido de 5 mg\/kg\/h\/1,5h. Se evaluaron los par\u00e1metros hemost\u00e1ticos: plaquetas, fibrin\u00f3geno, prote\u00edna c (pc), actividad pai y tiempos de coagulaci\u00f3n (ttpa y tp); citocinas: actividad tnf-alfa e il-1beta; quimocinas: cxcl-8 y groalfa; creatinina, urea y pam, a las 0,2,4 y 6 horas del inicio del experimento. se evalu\u00f3 la mortalidad a las 24 horas y se analizaron los dep\u00f3sitos renales y pulmonares de fibrina, as\u00ed como estudio inmunohistoqu\u00edmico de factor tisular renal.  resultados y discusi\u00f3n  fr167653 inhibi\u00f3 de forma dosis-dependiente la actividad tnf-alfa. El ac mo tambi\u00e9n inhibi\u00f3 eficazmente la actividad tnf-alfa. No se detectaron apenas niveles de il-1beta en ambos estudios, lo que no permite extraer conclusiones sobre el papel que juega esta citocina en la sepsis severa. a pesar de la eficaz inhibici\u00f3n de la<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estrategias de inhibici\u00f3n de citocinas proinflamatorias en un modelo de sepsis. impacto sobre las alteraciones hemost\u00e1ticas y la generaci\u00f3n de quimocinas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estrategias de inhibici\u00f3n de citocinas proinflamatorias en un modelo de sepsis. impacto sobre las alteraciones hemost\u00e1ticas y la generaci\u00f3n de quimocinas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Pablo Rodr\u00edguez Wilhelmi <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 07\/11\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ram\u00f3n Montes D\u00edaz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: domingo Espinos perez <\/li>\n<li>Francisco Espa\u00f1a furi\u00f3 (vocal)<\/li>\n<li>ignacio Moriyon uria (vocal)<\/li>\n<li>pablo Garc\u00eda de frutos (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Pablo Rodr\u00edguez Wilhelmi Introducci\u00f3n se cree que el tnf-alfa y la il-1beta son mediadores de la endotoxina [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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