{"id":26753,"date":"2003-10-11T00:00:00","date_gmt":"2003-10-11T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-patobiologica-del-melanoma-uveal\/"},"modified":"2003-10-11T00:00:00","modified_gmt":"2003-10-11T00:00:00","slug":"caracterizacion-patobiologica-del-melanoma-uveal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/malaga\/caracterizacion-patobiologica-del-melanoma-uveal\/","title":{"rendered":"Caracterizaci\u00f3n patobiologica del melanoma uveal"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Matilla Rodero M. Carmen <\/strong><\/h2>\n<p>El melanoma uveal constituye un tumor relativamente infrecuente, cuya histopatolog\u00eda y cl\u00ednica son bien conocidos. No obstante, existe gran controversia en cuanto a las opciones terap\u00e9uticas, su comportamiento biol\u00f3gico resulta ciertamente enigm\u00e1tico quiz\u00e1s por el desconocimiento de aspectos b\u00e1sicos referidos a la iniciaci\u00f3n, transformaci\u00f3n y progresi\u00f3n neopl\u00e1sica en estas lesiones melanoc\u00edticas del globo ocular.  en este trabajo -realizado en una amplia serie de melanomas uveales primitivos (diagnosticados y tratados, mediante enucleaci\u00f3n, en diferentes centros)-se pretende:  a) comprobar si el inmunofenotipo  del melanoma uveal es semejante al del melanoma en otras localizaciones.  b) conocer la interrelaci\u00f3n entre los diferentes aspectos cito-histopatol\u00f3gicos del tumor y diferentes par\u00e1metros patobiol\u00f3gicos, tales como el perfil inmunohistoqu\u00edmico de proliferaci\u00f3n (ki-67), de expresi\u00f3n de oncogenes (bcl-2, c-erbb2) y genes supresores (p53).  en la serie estudiad, la edad de los pacientes con melanoma de la \u00favea oscila entre 20 y 82 a\u00f1os, con una media global de 64,1a\u00f1os, existiendo un ligero predominio en el sexo femenino. La localizaci\u00f3n del melanoma del tracto uveal muestra una marcada preferencia por la coroides, seguida a gran distancia por el cuerpo ciliar y por el iris. El tama\u00f1o, establecido con criterios anatomopatol\u00f3gicos (seg\u00fan su di\u00e1metro mayor), es menor en los melanomas de coroides que en los ubicados en el iris o en el cuerpo ciliar.  en los melanomas uveales, se advierte un predominio del tipo celular fusiforme, seguido en frecuencia por el mixto y, a continuaci\u00f3n, por la variante epitelioide. la disparidad de estos datos con algunas otras series se debe a la falta de consenso entre los pat\u00f3logos para catalogar un melnoma uveal como tipo mixto. Estimamos que el porcentaje de c\u00e9lulas epitelioides superior al 5% es el requisito m\u00e1s adecuado para clasificar como mixto a un melanoma uvea<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n patobiologica del melanoma uveal<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n patobiologica del melanoma uveal <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Matilla Rodero M. Carmen <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 M\u00e1laga<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/11\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Alfredo Matilla Vicente<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: hugo Galera davidson <\/li>\n<li>joaquin Amerigo navarro (vocal)<\/li>\n<li>alfredo Blanes berenguel (vocal)<\/li>\n<li>angel Cilveti puche (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Matilla Rodero M. Carmen El melanoma uveal constituye un tumor relativamente infrecuente, cuya histopatolog\u00eda y cl\u00ednica son [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[7834],"tags":[7893,7890,65347,7891,24844,77225],"class_list":["post-26753","post","type-post","status-publish","format-standard","hentry","category-malaga","tag-alfredo-blanes-berenguel","tag-alfredo-matilla-vicente","tag-angel-cilveti-puche","tag-hugo-galera-davidson","tag-joaquin-amerigo-navarro","tag-matilla-rodero-m-carmen"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/26753","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=26753"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/26753\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=26753"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=26753"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=26753"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}