{"id":26755,"date":"2003-10-11T00:00:00","date_gmt":"2003-10-11T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-analogos-de-la-l-arginina-en-arteria-renal-humana\/"},"modified":"2003-10-11T00:00:00","modified_gmt":"2003-10-11T00:00:00","slug":"efecto-de-analogos-de-la-l-arginina-en-arteria-renal-humana","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-analogos-de-la-l-arginina-en-arteria-renal-humana\/","title":{"rendered":"Efecto de an\u00e1logos de la l-arginina en arteria renal humana"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Rogla Benedito Juan  Jos\u00e9 <\/strong><\/h2>\n<p>En algunas patolog\u00edas como la insuficiencia renal cr\u00f3nica, hipertensi\u00f3n, diabetes, hipercolesterolemia y la insuficiencia cardiaca los niveles plasm\u00e1ticos de dimetil-l-argomoma (adma), monometil-l-arginina (l-nmma) se encuentran aumentados. Este trabajo se ha realizado con el fin de valorar en la arteria renal humana:  1,- los efectos de adma, l-nmma, metilguanidina (mg) y aminoguanidina (ag) sobre la liberaci\u00f3n basal de \u00f3xido n\u00edtrico (no) y la relajaci\u00f3n dependiente e independiente del endotelio.  2,- la de los canales de k+ en la relajaci\u00f3n dependiente del endotelio.  los segmentos arteriales se montaron en un ba\u00f1o de \u00f3rganos para el registro de tensi\u00f3n isom\u00e9trica.  nuestros resultados indican que l-nmma y adma producen contrataci\u00f3n dependiente de la concentraci\u00f3n y del endotelio, que revierte en presencia de l-arginina (precursor del \u00f3xido n\u00edtrico). Sin embargo, ag y mg inducen una contracci\u00f3n independiente del endotelio. Por otra parte, l-nmma y adma bloquean, al menos en parte, la relajaci\u00f3n dependiente del endotelio inducida por la acetilcolina. Este bloqueo revierte con l-arginina. En conjunto podemos concluir que que l-nmma y adma disminuyen la liberaci\u00f3n basal e inducida de no endotelial en arterias renales humanas.  l-nmma, adma, mg y ag no alteran la respuesta al nitroprusiasto s\u00f3dico, un dador de no por tanto estos compuestos no modifican la capacidad relajante del m\u00fasculo liso vascular.  parte de la relajaci\u00f3n a la acetilcolina puede ser debida a la participaci\u00f3n del un factor hiperpolarizante derivado del endotelio de naturaleza no protanoide e indpendiente del no que act\u00faa a trav\u00e9s de canales de k+ de intermedia conductancia activados por ca2+.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de an\u00e1logos de la l-arginina en arteria renal humana<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de an\u00e1logos de la l-arginina en arteria renal humana <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Rogla Benedito Juan  Jos\u00e9 <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/11\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Cristina Domenech P\u00e9rez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas Herreros gonzalez <\/li>\n<li>Antonio  Jos\u00e9 Chover gonzalez (vocal)<\/li>\n<li>Javier Romero g\u00f3mez (vocal)<\/li>\n<li>joaquin Ortega serrano (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rogla Benedito Juan Jos\u00e9 En algunas patolog\u00edas como la insuficiencia renal cr\u00f3nica, hipertensi\u00f3n, diabetes, hipercolesterolemia y la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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