{"id":26788,"date":"2003-12-11T00:00:00","date_gmt":"2003-12-11T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-la-tolerancia-a-agentes-opioides-en-la-expresion-del-receptor-opioide-kappa\/"},"modified":"2003-12-11T00:00:00","modified_gmt":"2003-12-11T00:00:00","slug":"efecto-de-la-tolerancia-a-agentes-opioides-en-la-expresion-del-receptor-opioide-kappa","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/salamanca\/efecto-de-la-tolerancia-a-agentes-opioides-en-la-expresion-del-receptor-opioide-kappa\/","title":{"rendered":"Efecto de la tolerancia a agentes opioides en la expresi\u00f3n del receptor opioide kappa"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Herr\u00e1ez Baranda Luis Antonio <\/strong><\/h2>\n<p>En esta tesis doctoral planteamos la hip\u00f3tesis de que la tolerancia a los f\u00e1rmacos opioides que interaccionan con el receptor opioide kappa est\u00e1 relacionada con cambios en sus niveles de expresi\u00f3n. Para demostrar esta hip\u00f3tesis inducimos tolerancia a un agonista opioide inespec\u00edfico (morfina) y a un agonista espec\u00edfico kappa (u-50,488h) en ratas. Una vez obtenidos los animales tolerantes, comparamos los cambios en la expresi\u00f3n del receptor opioide k entre los estadios tolerante y control mediante la t\u00e9cnica de hibridaci\u00f3n in situ. Los niveles de expresi\u00f3n se cuantificaron en dos puntos cruciales de las v\u00edas nociceptivas, la sustancia gris periacueductal y las l\u00e1minas i y ii del asta dorsal de la m\u00e9dula espinal. Los resultados obtenidos muestras diferencias en la expresi\u00f3n del receptor opioide kappa entre las ratas tolerantes a morfina y sus controles en las columnas lateral y dorsal de la sustancia gris periacueductal, mientras que no se detectan cambios ni en las columnas dorsolateral ni ventrolateral del mismo \u00e1rea anat\u00f3mica, ni en las l\u00e1minas i y ii del asta dorsal de la m\u00e9dula espinal. respecto a las ratas tolerantes a u-50,4088h, no es posible evaluar si hay diferencias estad\u00edsticamente significativas en la expresi\u00f3n de este receptor debido a la falta de independencia muestral. Adem\u00e1s, la disminuci\u00f3n de la expresi\u00f3n del receptor opioide kappa ante la exposici\u00f3n prolongada a la morfina que hemos detectado nos permite postular un nuevo modelo que explica por primera vez porqu\u00e9 la tolerancia a agonistas tipo mu puede ser revertida mediante la administraci\u00f3n simult\u00e1nea de agonistas tipo kappa.  por otra parte, en esta tesis doctoral presentamos, por primera vez, pruebas concluyentes sobre la existencia del rna mensajero codificante para el receptor opioide kappa en el cerebelo de la rata. Esta expresi\u00f3n sucede tanto en la capa granular como en la molecular y en neuronas y c\u00e9lulas gliales.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de la tolerancia a agentes opioides en la expresi\u00f3n del receptor opioide kappa<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de la tolerancia a agentes opioides en la expresi\u00f3n del receptor opioide kappa <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Herr\u00e1ez Baranda Luis Antonio <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/11\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Raquel Emilia Rodr\u00edguez Rodr\u00edguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: gregorio Valenica <\/li>\n<li>Manuel Rubio s\u00e1nchez (vocal)<\/li>\n<li>isabel julia Pastor encinas (vocal)<\/li>\n<li>gemma Arsequell ruiz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Herr\u00e1ez Baranda Luis Antonio En esta tesis doctoral planteamos la hip\u00f3tesis de que la tolerancia a los [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9386],"tags":[76114,77305,77304,77306,9524,47682],"class_list":["post-26788","post","type-post","status-publish","format-standard","hentry","category-salamanca","tag-gemma-arsequell-ruiz","tag-gregorio-valenica","tag-herraez-baranda-luis-antonio","tag-isabel-julia-pastor-encinas","tag-manuel-rubio-sanchez","tag-raquel-emilia-rodriguez-rodriguez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/26788","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=26788"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/26788\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=26788"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=26788"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=26788"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}