{"id":26886,"date":"2018-03-09T09:18:54","date_gmt":"2018-03-09T09:18:54","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/funcion-fisiologica-sobre-la-respuesta-inmune-e-inflamatoria-de-la-molecula-inducible-durante-la-activacion-leucocitaria-cd69\/"},"modified":"2018-03-09T09:18:54","modified_gmt":"2018-03-09T09:18:54","slug":"funcion-fisiologica-sobre-la-respuesta-inmune-e-inflamatoria-de-la-molecula-inducible-durante-la-activacion-leucocitaria-cd69","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/funcion-fisiologica-sobre-la-respuesta-inmune-e-inflamatoria-de-la-molecula-inducible-durante-la-activacion-leucocitaria-cd69\/","title":{"rendered":"Funci\u00f3n fisiol\u00f3gica sobre la respuesta inmune e inflamatoria de la mol\u00e9cula inducible durante la activaci\u00f3n leucocitaria cd69"},"content":{"rendered":"<h2>Tesis doctoral de <strong> David Sancho Madrid <\/strong><\/h2>\n<p>Cd69 es una lectina tipo c que se induce muy r\u00e1pidamente tras la activaci\u00f3n leucocitaria. En el presente trabajo demostramos que los dominios de uni\u00f3n a ligando y transducci\u00f3n de la se\u00f1al de cd69 y cd23 otra lectina tipo c, act\u00faan de manera independiente y que la se\u00f1al transducida depende de la regi\u00f3n citopl\u00e1smica. Adem\u00e1s, hemos encontrado que la interacci\u00f3n y migraci\u00f3n a trav\u00e9s del endotelio aumenta la expresi\u00f3n de cd69  a trav\u00e9s de la interacci\u00f3n lfa-1\/icam-1. Para investigar la funci\u00f3n in vivo de cd69, generamos el rat\u00f3n deficiente en cd69. La selecci\u00f3n t\u00edmica es normal y s\u00f3lo se encontr\u00f3 un leve aumento de la poblaci\u00f3n pre-b en m\u00e9dula \u00f3sea. Puesto que cd69 se expresa en leucocitos infiltrantes en los focos inflamatorios, se explor\u00f3 el papel de cd69 en la reactividad autoinmune con un modelo animal de artritis inducida por col\u00e1geno (cia). Los ratones cd69-\/- mostraron mayor incidencia y severidad de la cia, con respuestas t y b exacerbadas al col\u00e1geno tipo ii. Los niveles de mrna y prote\u00edna para el factor de crecimiento transformante (tgf)-beta 1 y 2, que act\u00faa como citocina protectora en cia, se reduc\u00edan en los focos inflamatorios de los ratones deficientes para cd69, correlacionando con un aumento en citocinas proinflamatorias. La inyecci\u00f3n local de anti-tgf-beta bloqueante aument\u00f3 la severidad de la cia y los niveles de mrna en los ratones cd69+\/+ pero no en los ratones cd69-\/-, confirmando que la deficiencia en tgf-beta explica el aumento de inflamaci\u00f3n y sugiriendo su relaci\u00f3n con la ausencia de cd69. El tratamiento in vivo con anti-cd69 bloqueante confirm\u00f3 en un modelo independiente de artritis que el bloqueo de la interacci\u00f3n de cd69 con su ligando lleva a disminuci\u00f3n local de tgf-beta y aumento de inflamaci\u00f3n. El tratamiento in vitro de cd69 con anticuerpos agonistas indujo la producci\u00f3n de tgf-beta, estableciendo una conexi\u00f3n directa. Nuestros resultados muestran que la funci\u00f3n no redunda<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Funci\u00f3n fisiol\u00f3gica sobre la respuesta inmune e inflamatoria de la mol\u00e9cula inducible durante la activaci\u00f3n leucocitaria cd69<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Funci\u00f3n fisiol\u00f3gica sobre la respuesta inmune e inflamatoria de la mol\u00e9cula inducible durante la activaci\u00f3n leucocitaria cd69 <\/li>\n<li><strong>Autor:<\/strong>\u00a0 David Sancho Madrid <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/11\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Sanchez Madrid<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Ort\u00edz de land\u00e1zuri busca <\/li>\n<li>pedro Aparicio alonso (vocal)<\/li>\n<li>federico Mayor menendez (vocal)<\/li>\n<li>balbino Jos\u00e9 Alarcon sanchez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de David Sancho Madrid Cd69 es una lectina tipo c que se induce muy r\u00e1pidamente tras la activaci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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